Practice effects and amyloid deposition: preliminary data on a method for enriching samples in clinical trials.
Practice effects and amyloid deposition: preliminary data on a method for enriching samples in clinical trials.
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DOI：
10.1097/wad.0000000000000021
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发表时间：
2014-07
影响因子：
2.1
通讯作者：
Hoffman JM
中科院分区：
文献类型：
--
作者：
Duff K;Foster NL;Hoffman JM
Clinical trials in Alzheimer’s disease are moving towards prevention studies in prodromal individuals with amyloid burden. However, methods are needed to identify individuals expected to be amyloid positive for these studies to be feasible and cost effective. The current study sought to determine whether short-term practice effects on cognitive tests can identify those with notable uptake on amyloid imaging. Twenty-five, non-demented older adults (15 cognitively intact, 10 Mild Cognitive Impairment) underwent amyloid imaging via 18F-flutemetamol and two cognitive testing sessions across one week to determine practice effects on a visual memory test. Results indicated that whereas 18F-flutemetamol uptake showed little association with baseline performance on a visual memory test (r=−0.04, p=0.85), it was significantly correlated with practice effects across one week on that same memory measure (r=−0.45, p=0.02), with greater uptake being associated with lower practice effects. The odds ratio of notable 18F-flutemetamol uptake was 5 times higher in individuals with low practice effects compared to high practice effects. Although these preliminary results need to be replicated in larger samples, short-term practice effects on cognitive tests may provide an affordable screening method to identify individuals who are amyloid positive, which could enrich samples for preventative clinical trials in Alzheimer’s disease.
