RATE AND EQUILIBRIUM DATA FOR SUBSTITUTION-REACTIONS OF DIAQUA(ETHYLENEDIAMINE)PALLADIUM(II) WITH CHLORIDE IN AQUEOUS-SOLUTION
RATE AND EQUILIBRIUM DATA FOR SUBSTITUTION-REACTIONS OF DIAQUA(ETHYLENEDIAMINE)PALLADIUM(II) WITH CHLORIDE IN AQUEOUS-SOLUTION
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DOI：
10.1016/s0020-1693(00)80282-0
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发表时间：
1990-08-01
影响因子：
2.8
通讯作者：
VANELDIK, R
中科院分区：
文献类型：
--
作者：
HOHMANN, H;VANELDIK, R
报道了复杂生成反应的动力学和热力学数据。这些物种可以作为抗肿瘤活性- pt (NH3) 2cl2复合物机制行为的模型。Pd(en) cl2在水溶液中自发溶解生成Pd(en)(H2O)Cl+和Pd(en)(H2O)22+。采用分光光度法和电位法测定平衡常数，K1= 4000, k2 = 137 M−1,25℃，0.1 M离子强度。在此条件下，双水络合物的酸解离常数分别为（pKa） 5.6和7.3。Pd(en)(H2O)22+被Cl−阳离子化的速率常数为3.0 × 104M−1s−1，而Pd(en)- (H2O)Cl+被Cl−在25℃和0.1 M离子强度下的阳离子化速率常数为1.3 × 103M−1s−1。动力学数据用于确定复杂地层常数，并与上述报告进行了比较。结合现有文献资料，对研究结果进行了讨论。
Kinetic and thermodynamic data are reported for the complex formation reactions.These species serve as models for the mechanistic behaviour of the antitumor activecis-Pt(NH3)2Cl2complex. Pd(en)Cl2undergoes spontaneous solvolysis in aqueous solution to produce Pd(en)(H2O)Cl+and Pd(en)(H2O)22+. Spectrophotometric and potentiometric techniques were employed to determine the equilibrium constant,K1= 4000 andK2= 137 M−1at 25 °C and 0.1 M ionic strength. The acid dissociation constants for the diaqua complex were found to be (pKa) 5.6 and 7.3 under these conditions. Anation of Pd(en)(H2O)22+by Cl−occurs with a rate constant of 3.0 × 104M−1s−1, compared to a value of 1.3 × 103M−1s−1for the anation of Pd(en)- (H2O)Cl+by Cl−at 25°C and 0.1 M ionic strength. The kinetic data were used to determine complex formation constants, which are compared with those reported above. The results are discussed in reference to the available literature information.