Analysis of spectral-domain optical coherence tomography measurements in amblyopia: a pilot study
Analysis of spectral-domain optical coherence tomography measurements in amblyopia: a pilot study
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DOI：
10.1136/bjo.2010.192765
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发表时间：
2011-12-01
影响因子：
4.1
通讯作者：
Oh, Sei Yeul
中科院分区：
文献类型：
--
作者：
Park, Kyung-Ah;Park, Do Young;Oh, Sei Yeul
目的比较单眼弱视患者与对侧眼视网膜各层厚度的差异。方法对20例单眼弱视患者进行水平和垂直方向的光谱域光学相干断层扫描。测量弱视眼视网膜各层的厚度，分别位于中心凹中心、黄斑内区和黄斑区，（中心凹中心上方、下方、鼻侧和颞侧平均490 mm和500 mm上级）和外部黄斑位置（平均1490 mm和1500 mm上、下上级，鼻侧和颞侧至中心凹中心），并与对侧眼的相应位置进行比较。在所有四个鼻和颞部黄斑位置以及外部上级和下级位置，神经节细胞层和内网状层均显著变薄。其他视网膜层，包括神经纤维层，内核层，外丛状层和外核层，表现出显着差异的厚度在几个黄斑locations.Conclusions这些数据，获得使用光谱域光学相干断层扫描，揭示弱视和同胞的眼睛之间的差异，在一些视网膜层的厚度，包括一个显着的差异，在神经节细胞层加内丛状层。
Background/aims To compare the thickness of each retinal layer of amblyopic and fellow eyes in patients with unilateral amblyopia.Methods Horizontal and vertical spectral-domain optical coherence tomography scans through the fovea were obtained for 20 patients with unilateral amblyopia. The thickness of each retinal layer in the amblyopic eyes was measured at the foveal centre, inner macular locations (a mean of 490 mm and 500 mm superior, inferior, nasal and temporal to the foveal centre) and outer macular locations (a mean of 1490 mm and 1500 mm superior, inferior, nasal and temporal to the foveal centre) and compared with corresponding locations in the fellow eyes.Results In amblyopic eyes, there was significant thinning of the ganglion cell layer plus inner plexiform layer at all four nasal and temporal macular locations and at the outer superior and inferior locations. Other retinal layers, including the nerve fibre layer, inner nuclear layer, outer plexiform layer and outer nuclear layer, demonstrated significant differences in thickness at several macular locations.Conclusions These data, obtained using spectral-domain optical coherence tomography, reveal differences between amblyopic and fellow eyes in the thickness of some retinal layers, including a notable difference in the ganglion cell layer plus inner plexiform layer.