Barrel Cortex Membrane Potential Dynamics in Social Touch
Barrel Cortex Membrane Potential Dynamics in Social Touch
复制标题
DOI：
10.1016/j.neuron.2014.12.059
复制
发表时间：
2015-02-18
期刊：
影响因子：
16.2
通讯作者：
Brecht, Michael
中科院分区：
文献类型：
--
作者：
Lenschow, Constanze;Brecht, Michael
社会刺激对桶皮层神经元的膜电位动力学的影响是未知的。我们获得了在体内全细胞记录在桶皮质的头部限制大鼠，而他们与同种相互作用。社交接触与去极化和大的膜电位波动相关，这些波动锁定在老鼠的搅拌上。在接触前已经观察到去极化和膜电位波动，并且在自由搅拌期间没有发生。这种预期的接触前去极化在麻醉动物的被动社会接触中没有发现。在与清醒同种的相互作用中观察到的锁定在大鼠搅动上的膜电位波动大于在非同种刺激（填充大鼠、物体和实验者的手）上观察到的搅动。反应与胡须运动参数无关。我们的结论是，社会触摸的反应不同于传统的触觉反应（1）振幅，（2）锁定搅拌，（3）接触前膜电位的变化。
The impact of social stimuli on the membrane potential dynamics of barrel cortex neurons is unknown. We obtained in vivo whole-cell recordings in the barrel cortex of head-restrained rats while they interacted with conspecifics. Social touch was associated with a depolarization and large membrane potential fluctuations locked to the rat's whisking. Both depolarization and membrane potential fluctuations were already observed prior to contact and did not occur during free whisking. This anticipatory pre-contact depolarization was not seen in passive social touch in anesthetized animals. The membrane potential fluctuations locked to the rat's whisking observed in interactions with awake conspecifics were larger than those seen for whisking onto nonconspecific stimuli (stuffed rats, objects, and the experimenter's hand). Responses did not correlate with whisker movement parameters. We conclude that responses to social touch differ from conventional tactile responses in (1) amplitude, (2) locking to whisking, and (3) pre-contact membrane potential changes.