Analyzing the Metabolism of Metastases in Mice
Analyzing the Metabolism of Metastases in Mice
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DOI：
10.1007/978-1-0716-0159-4_6
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Fendt, Sarah-Maria
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文献类型：
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作者：
Altea-Manzano, Patricia;Broekaert, Dorien;Fendt, Sarah-Maria
转移形成是癌症患者死亡的主要原因。最近发现，癌细胞适应它们的代谢以成功地通过转移级联过渡。因此，测量和分析转移瘤的体内代谢有可能揭示预防转移瘤形成的新治疗策略。在这里，我们描述了两种不同的转移小鼠模型，以及如何用代谢组学和C-13示踪分析来分析它们的代谢。
Metastasis formation is the leading cause of death in cancer patients. It has recently emerged that cancer cells adapt their metabolism to successfully transition through the metastatic cascade. Consequently, measuring and analyzing the in vivo metabolism of metastases has the potential to reveal novel treatment strategies to prevent metastasis formation. Here, we describe two different metastasis mouse models and how their metabolism can be analyzed with metabolomics and C-13 tracer analysis.