Aluminum toxicokinetics regarding infant diet and vaccinations
Aluminum toxicokinetics regarding infant diet and vaccinations
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DOI：
10.1016/s0264-410x(02)00165-2
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发表时间：
2002-05-31
期刊：
影响因子：
5.5
通讯作者：
Chou, CHSJ
中科院分区：
文献类型：
--
作者：
Keith, LS;Jones, DE;Chou, CHSJ
一些疫苗含有铝佐剂以增强免疫反应，并且已经假定这种铝可能导致不良健康影响，特别是在从出生开始接受疫苗接种系列的儿童中。介绍了铝的药代动力学特性和终点毒性。在评估饮食和医疗铝暴露与公共卫生的相关性时，我们估计了婴儿在出生后第一年母乳和配方奶粉饮食以及标准疫苗接种计划的身体负担。然后，我们将这些身体负担与预期的摄入量进行了比较，该摄入量被认为是中期暴露的安全水平。该方法混合摄入值和摄取分数与来自人体注射研究使用放射性Al-26的铝保留功能。计算出的疫苗接种铝的身体负荷超过了饮食来源，但是，它低于最低风险水平等效曲线后，短暂的注射后。爱思唯尔科技有限公司出版
Some vaccines contain aluminum adjuvants to enhance the immunological response, and it has been postulated that this aluminum could contribute to adverse health effects, especially in children who receive a vaccination series starting at birth. The pharmacokinetic properties and end-point toxicities of aluminum are presented. In assessing the relevance of dietary and medical aluminum exposure to public health, we estimated infant body burdens during the first year of life for breast milk and formula diets and for a standard vaccination schedule. We then compared those body burdens with that expected for intake at a level considered safe for intermediate-duration exposure. The methodology blends intake values and uptake fractions with an aluminum retention function derived from a human injection study using radioactive Al-26. The calculated body burden of aluminum from vaccinations exceeds that from dietary sources, however, it is below the minimal risk level equivalent curve after the brief period following injection. Published by Elsevier Science Ltd.