INCREASED PLASMA-LEVELS OF THE NOVEL VASOCONSTRICTOR PEPTIDE ENDOTHELIN IN SEVERE PREECLAMPSIA
INCREASED PLASMA-LEVELS OF THE NOVEL VASOCONSTRICTOR PEPTIDE ENDOTHELIN IN SEVERE PREECLAMPSIA
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DOI：
10.1016/0028-2243(91)90120-a
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发表时间：
1991-07-25
期刊：
影响因子：
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通讯作者：
VANKAMP, GJ
中科院分区：
文献类型：
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作者：
DEKKER, GA;KRAAYENBRINK, AA;VANKAMP, GJ
本文对29例妊娠妇女血浆内皮素水平进行了研究，发现9例妊娠合并高血压疾病和/或先兆子痫的孕妇血浆内皮素水平升高，而14例妊娠24-40周的正常孕妇血浆内皮素水平升高，子宫弓状动脉多普勒血流速度波形正常。6例正常妊娠24周多普勒血流速度波形异常，2例重度子痫前期患者血浆内皮素水平升高，提示血浆内皮素水平与疾病进程相关。 内皮素是由血管内皮细胞产生的，它是迄今为止已知的最有效的血管收缩剂。 由于这个原因，已经提出内皮素可能在控制全身血压和局部血流中是重要的，这两者在先兆子痫中都受到干扰。 本研究的结论是，静脉血浆内皮素水平似乎是严重疾病的标志物，但没有任何预测价值。
Plasma endothelin levels were studied in 29 pregnancies.Levels were found to be increased in 9 pregnancies complicated by pregnancy-induced hypertensive disease and/or pre-eclampsia as compared to levels in 14 normotensive pregnancies with gestational age varying between 24-40 weeks with normal Doppler flow velocity waveforms of the uterine arcuate arteries, and 6 normotensive pregnancies with abnormal Doppler flow velocity waveforms at 24 weeks' gestation.Two patients with severe pre-eclampsia showed a rise in plasma endothelin levels, suggesting a correlation between plasma endothelin levels and the disease process. Endothelin is produced by endothelial cells of blood vessels; it is the most potent vasoconstrictor known to date. For this reason it has been suggested that endothelin might be important in the control of systemic blood pressure and local blood flow, both disturbed in pre-eclampsia. The conclusion of this study is that the venous plasma level of endothelin would seem to be a marker for severe disease, however, without any predictive value.