Emotional learning enhances stimulus-specific top-down modulation of sensorimotor gating in socially reared rats but not isolation-reared rats
Emotional learning enhances stimulus-specific top-down modulation of sensorimotor gating in socially reared rats but not isolation-reared rats
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DOI：
10.1016/j.bbr.2009.09.012
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发表时间：
2010-01-01
影响因子：
2.7
通讯作者：
Li, Liang
中科院分区：
文献类型：
--
作者：
Du, Yi;Wu, Xihong;Li, Liang
前脉冲抑制（PPI），通过先前的感觉刺激（前脉冲）抑制惊吓反射，可以在人类和大鼠中自上而下调节。本研究探讨情绪学习诱导的PPI增强是否具有前脉冲特异性。结果表明，在社会饲养的大鼠，PPI引起的窄带噪声前脉冲的宽带噪声背景（掩蔽）增强后，前脉冲成为恐惧条件。通过在条件前脉冲和宽带噪声掩蔽之间引入感知空间分离，这种恐惧条件调制的PPI得到进一步增强。然而，如果条件前脉冲被一个不同的窄带噪声前脉冲所取代，这些PPI增强消失了，而这个窄带噪声前脉冲不是恐惧条件的。在隔离饲养的大鼠，谁都增强了基线惊吓和减少PPI前的条件，既不恐惧条件的前脉冲，也没有感知到的空间分离之间的条件前脉冲和噪声掩蔽可以增强PPI。因此，情感学习诱导的PPI在社会饲养的大鼠增强是前脉冲特异性的，表明听觉处理与记忆信号相互作用，形成自上而下的调制PPI。由于精神分裂症患者的PPI注意调节缺陷与症状严重程度相关，因此隔离饲养大鼠的PPI自上而下调节缺陷可用于精神分裂症的建模。(C)2009 Elsevier B.V.保留所有权利。
Prepulse inhibition (PPI), the suppression of the startle reflex by a preceding sensory stimulus (prepulse), can be top-down modulated in both humans and rats. This study investigated whether emotional-learning-induced enhancement of PPI in rats is prepulse specific. The results show that in socially reared rats, PPI elicited by a narrowband-noise prepulse on the broadband-noise background (masker) was enhanced after the prepulse became fear conditioned. This fear-conditioning-modulated PPI was further enhanced by introducing a perceived spatial separation between the conditioned prepulse and the broadband-noise masker. However, these PPI enhancements disappeared if the conditioned prepulse was replaced by a different narrowband-noise prepulse that was not fear conditioned. In isolation-reared rats, who had both enhanced baseline startle and reduced PPI before conditioning, neither fear conditioning of the prepulse nor perceived spatial separation between the conditioned prepulse and noise masker could enhance PPI. Thus, the emotional-learning-induced enhancement of PPI in socially reared rats is prepulse specific, indicating that auditory processing interacts with mnemonic signaling in the formation of top-down modulation of PPI. Since the deficiency of attentional modulation of PPI in schizophrenic patients is correlated with the symptom severity, the deficiency of top-down modulations of PPI in isolation-reared rats is useful for modeling schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.