Oxidative stress and neopterin abnormalities in schizophrenia: A longitudinal study
Oxidative stress and neopterin abnormalities in schizophrenia: A longitudinal study
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DOI：
10.1016/j.jpsychires.2009.09.002
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发表时间：
2010-04-01
影响因子：
4.8
通讯作者：
Gangadhar, Bangalore N.
中科院分区：
文献类型：
--
作者：
Chittiprol, Seetharamaiah;Venkatasubramanian, Ganesan;Gangadhar, Bangalore N.
氧化应激异常被认为可以解释精神分裂症的发病机制。本研究检测了精神分裂症患者治疗前后的新蝶呤和氧化应激异常。在治疗前与健康对照（n = 43）比较，对45例抗精神病初治精神分裂症患者（n = 45）的血清新卵磷脂、总抗氧化剂、亚硝酸盐和硫醇进行基线评估。对正在治疗的精神分裂症患者随访3个月，重新评估这些参数（n = 32）。与健康对照组相比，精神分裂症患者在治疗前的新蝶呤和亚硝酸盐水平明显较高，抗氧化剂水平明显较低。在精神分裂症患者接受抗精神病药物治疗后的随访评估中，新蝶呤水平显著降低，抗氧化水平显著升高。我们的研究结果支持精神分裂症患者氧化应激增加，抗精神病药物治疗可改善氧化应激。2009爱思唯尔有限公司版权所有。
Oxidative stress abnormalities have been proposed to explain the pathogenesis of schizophrenia. The present study examined neopterin and oxidative stress abnormalities in schizophrenia patients before and after treatment. Serum neopterin, total anti-oxidants, nitrites and thiols in antipsychotic-naive schizophrenia patients (n = 45) were assessed at baseline before treatment in comparison with healthy controls (n = 43). The schizophrenia patients on treatment were followed up for 3 months and these parameters were reassessed (n = 32). In comparison to healthy controls, schizophrenia patients had significantly higher levels of neopterin and nitrites and significantly lower levels of anti-oxidants before treatment. During follow-up assessments in schizophrenia patients after treatment with antipsychotics, there was a significant decrease in the neopterin levels and significant increase in anti-oxidant levels. Our study observations support increased oxidative stress in schizophrenia that improves with antipsychotic treatment. (C) 2009 Elsevier Ltd. All rights reserved.