MIA (melanoma inhibitory activity):: a potential serum marker for rheumatoid arthritis
MIA (melanoma inhibitory activity):: a potential serum marker for rheumatoid arthritis
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DOI：
10.1093/rheumatology/38.2.148
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发表时间：
1999-02-01
期刊：
影响因子：
5.5
通讯作者：
Lang, B
中科院分区：
文献类型：
--
作者：
Müller-Ladner, U;Bosserhoff, AK;Lang, B
目标。MIA(黑色素瘤抑制活性)与恶性黑色素瘤患者的转移有关。由于MIA不仅由黑色素瘤细胞产生，而且由分化的软骨细胞产生，我们检查了血清MIA水平是否与风湿性疾病的炎症和/或关节破坏有关。检测不同风湿性疾病患者的MIA血药浓度，并与健康人和恶性黑色素瘤患者进行比较。此外，MIA浓度与炎症参数和关节破坏相关。仅在与关节破坏相关的风湿性疾病患者中发现MIA血清浓度升高，如类风湿性关节炎(RA)、骨关节炎、人类白细胞抗原B27相关的少关节炎和牛皮癣关节炎。在这些风湿性疾病中，仅在类风湿因子(RF)阳性和关节破坏相关的RA患者中，MIA血清浓度显著升高。因此，除RF外，MIA可能有助于RA和非破坏性风湿性疾病的鉴别诊断，而血清MIA水平升高很可能反映了RA的联合破坏。
Objective. MIA (melanoma inhibitory activity) is correlated with metastasis in patients with malignant melanoma. As MIA is not only produced by melanoma cells, but also by differentiated chondrocytes, we examined whether serum levels of MIA are correlated with inflammation and/or joint destruction in rheumatic diseases.Methods. MIA serum concentrations of patients with different rheumatic diseases were examined and compared with healthy individuals and malignant melanoma patients. In addition, MIA concentrations were correlated to inflammatory parameters and joint destruction.Results. Increased MIA serum concentrations were found only in patients with rheumatic diseases associated with joint destruction, such as rheumatoid arthritis (RA), osteoarthritis, HLA B27-associated oligoarthritis, and psoriatic arthritis. Of these rheumatic diseases, a significant increase in MIA serum concentrations was seen only in patients with RA, associated with rheumatoid factor (RF) positivity and joint destruction.Conclusions. In addition to RF, MIA might therefore be useful in the differential diagnosis of RA vs non-destructive rheumatic diseases, and the presence of elevated levels of MIA in serum very likely reflects joint destruction in RA.