Metaiodobenzylguanidine [131I] Scintigraphy Detects Impaired Myocardial Sympathetic Neuronal Transport Function of Canine Mechanical‐Overload Heart Failure
Metaiodobenzylguanidine [131I] Scintigraphy Detects Impaired Myocardial Sympathetic Neuronal Transport Function of Canine Mechanical‐Overload Heart Failure
复制标题
间碘苄胍 [131I] 闪烁扫描检测犬机械超负荷心力衰竭心肌交感神经元运输功能受损
作者：
M. Rabinovitch;C. Rose;J. Rouleau;C. Chartrand;D. Wieland;L. Lepanto;F. Legault;S. Suissa;L. Rosenthall;J. Burgess
在慢性机械负荷超负荷继发的心力衰竭中，心脏交感神经元表现出儿茶酚胺合成和转运功能受抑。为评价交感神经显像术检测转运功能受抑的可能性，对13只正常犬、3只去神经自体移植犬、5只左心衰犬和5只因外科动静脉分流术后代偿性左室肥厚的犬静脉注射间碘苯基胍[131I]后，进行了一系列的核素扫描。注射后14小时处死9只犬，测定左房、左室、肝、脾组织中间苯并基胍[131I]和内源性去甲肾上腺素含量。在注射后4小时，自体移植犬的平均左心室示踪剂蓄积减少了39%，反映了神经元内示踪剂池的缺失。衰竭犬早期平均左心室示踪流出速度加快(26.0%/小时，正常为13.7%/小时)，反映神经元外示踪剂池不成比例地增加。他们还显示左心室晚期和左房的示踪剂浓度降低，这与神经元内示踪剂池的减少一致。相比之下，代偿性肥厚犬早期平均左心室示踪流出速度正常(16.4%/小时)，左心室晚期和左房示踪剂浓度基本正常。偏苯基胍[131I]核素扫描结果反映了犬机械负荷超负荷心力衰竭时心脏交感神经运输系统的完整性。间苯并[123I]放射性核素显像应作为早期发现患者机械负荷超负荷心力衰竭的一种手段。
In heart failure secondary to chronic mechanical overload, cardiac sympathetic neurons demonstrate depressed catecholamine synthetic and transport function. To assess the potential of sympathetic neuronal imaging for detection of depressed transport function, serial scintigrams were acquired after the intravenous administration of metaiodobenzylguanidine [131I] to 13 normal dogs, 3 autotransplanted (denervated) dogs, 5 dogs with left ventricular failure, and 5 dogs with compensated left ventricular hypertrophy due to a surgical arteriovenous shunt. Nine dogs were killed at 14 hours postinjection for determination of metaiodobenzylguanidine [131I] and endogenous norepinephrine content in left atrium, left ventricle, liver, and spleen. By 4 hours postinjection, autotransplanted dogs had a 39% reduction in mean left ventricular tracer accumulation, reflecting an absent intraneuronal tracer pool. Failure dogs demonstrated an accelerated early mean left ventricular tracer efflux rate (26.0%/hour versus 13.7%/hour in normals), reflecting a disproportionately increased extraneuronal tracer pool. They also showed reduced late left ventricular and left atrial concentrations of tracer, consistent with a reduced intraneuronal tracer pool. By contrast, compensated hypertrophy dogs demonstrated a normal early mean left ventricular tracer efflux rate (16.4%/hour) and essentially normal late left ventricular and left atrial concentrations of tracer. Metaiodobenzylguanidine [131I] scintigraphic findings reflect the integrity of the cardiac sympathetic neuronal transport system in canine mechanical-overload heart failure. Metaiodobenzylguanidine [123I] scintigraphy should be explored as a means of early detection of mechanical-overload heart failure in patients.
摄取一抑制剂对去甲肾上腺素和间碘苄胍摄取的影响。
DOI：
--
发表时间：
1985
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Tobes,MC;JaquesJr,S;Wieland,DM;Sisson,JC
通讯作者：
Sisson,JC
开发试剂盒形式的间碘苄基胍类似物。
DOI：
--
发表时间：
1986
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Lee,H;Inbasekaran,MN;Wieland,DM;Sherman,PS;Fisher,SJ;Mangner,TJ;Rogers,WL;Clinthorne,NH
通讯作者：
Clinthorne,NH