Association between interleukin 1β and interleukin 10 concentrations: a cross-sectional study in young adolescents in Taiwan
Association between interleukin 1β and interleukin 10 concentrations: a cross-sectional study in young adolescents in Taiwan
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DOI：
10.1186/1471-2431-13-123
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发表时间：
2013-08-14
期刊：
影响因子：
2.4
通讯作者：
Chao, Kuo-Ching
中科院分区：
文献类型：
--
作者：
Chang, Jung-Su;Chang, Chun-Chao;Chao, Kuo-Ching
背景：在成人中，低循环白细胞介素10 （IL10）与肥胖和2型糖尿病有关。然而，对超重和肥胖儿童中il - 10的研究得出了相互矛盾的结果。本研究的目的是探讨中国青少年血清IL10浓度的相关因素。方法：2010 - 2011年，年龄13.33+/-1.10岁的青少年（n=325）被纳入横断面研究。评估肥胖、代谢当量个体成分、铁状态和血清il - 10等参数。结果：与正常体重的同龄人相比，超重青少年的血清il - 10较低，而TNF - α、一氧化氮（NO）和il - 1 β浓度较高(均p
Background: In adults, low circulating interleukin 10 (IL10) has been associated with obesity and type 2 diabetes. However, studies investigating IL10 in overweight and obese children have yielded conflicting results. The aim of this study was to investigate factors associated with serum IL10 concentration in young Chinese adolescents.Methods: Young adolescents (n=325) ages 13.33+/-1.10 years were recruited into the cross-sectional study from 2010 to 2011. Parameters of obesity, individual components of MetS, iron status and serum IL10 were evaluated.Results: Compared with their normal weight counterparts, overweight adolescents had lower serum IL10 but higher TNF alpha, nitric oxide (NO) and IL1 beta concentrations (all p