Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men
Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men
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DOI：
10.1016/j.mad.2005.01.005
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发表时间：
2005-06-01
影响因子：
5.3
通讯作者：
Takashima, Y
中科院分区：
文献类型：
--
作者：
Kokaze, A;Ishikawa, M;Takashima, Y
线粒体DN5178胞嘧啶/腺嘌呤多态，又称NADH脱氢酶亚基-2237亮氨酸/蛋氨酸(ND2-237Leu/Met)多态，与日本人的长寿有关。这种多态与血压、血脂水平、血液学参数、眼压和血清蛋白质组分水平广泛相关。然而，关于ND2-237Leu/Met基因多态性与血清电解质水平的关系尚未见报道。为了研究这种关系，我们对321名健康的日本中年男性进行了一项关联性研究。原始数据显示，Nd2-237Met携带者的血钠水平和血清氯水平显著低于Nd2-237Leu携带者(P分别为0.021和0.003)。在ND2-237Leu基因携带者中，吸烟和体重指数与血清氯水平呈显著正相关(P=0.002和0.008)，与血红蛋白水平呈显著负相关(P=0.007)。在患有Nd2-237Met的男性中，只有血红蛋白水平与血清氯水平显著负相关(P=0.025)。在调整协变量后，只有男性肥胖(体重指数=25)受试者的血钠和氯离子水平保持在显著较低的水平，而血清钙水平似乎明显高于Nd2-237Leu组(分别为P=0.013、0.001和0.046)。长寿相关的NADH脱氢酶亚单位-2基因多态性可能影响日本中年肥胖男性的血清电解质水平。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Mitochondrial DNA 5178 cytosine/adenine polymorphism, which is also called NADH dehydrogenase subunit-2237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is associated with Japanese longevity. This polymorphism is widely associated with blood pressure, serum lipid levels, hematological parameters, intraocular pressure, and serum protein fraction levels. However, there have been no reports on the association between ND2-237 Leu/Met polymorphism and serum electrolyte levels. To investigate this relationship, we performed an association study in 321 healthy middle-aged Japanese men. Crude data showed that serum sodium levels and serum chloride levels were significantly lower in men with ND2-237 Met than in those with ND2-237 Leu (P = 0.021 and 0.003, respectively). Cigarette consumption and body mass index were significantly and positively associated with serum chloride levels (P = 0.002 and 0.008, respectively) and hemoglobin levels were significantly and negatively associated with them (P = 0.007) in ND2-237 Leu genotypic men. In men with ND2-237 Met, only hemoglobin levels were significantly and negatively associated with serum chloride levels (P = 0.025). After adjusting for covariates, only in male obese (body mass index >= 25) subjects, serum sodium and chloride levels remained significantly lower, and serum calcium levels appeared to be significantly higher in ND2-237 Met than in ND2-237 Leu (P = 0.013, < 0.001, and 0.046, respectively). Longevity-associated NADH dehydrogenase subunit-2 polymorphism may influence serum electrolyte levels in middle-aged obese Japanese men. (c) 2005 Elsevier Ireland Ltd. All rights reserved.