Functional Delivery Vehicle of Organic Nanoparticles in Inorganic Crystals
Functional Delivery Vehicle of Organic Nanoparticles in Inorganic Crystals
复制标题
无机晶体中有机纳米粒子的功能传递载体
DOI：
10.1016/j.cclet.2019.08.007
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发表时间：
2019
影响因子：
9.1
通讯作者：
Hanying Li
中科院分区：
文献类型：
--
作者：
Linlin Kong;Xinyi Jin;Dapeng Hu;Leyun Feng;Dong Chen;Hanying Li
生物活性物质的包封以延长保质期和受控的靶向释放对于其在食品和药物递送中的应用至关重要。在这里，已经开发了一种新的方法来封装生物活性分子的晶体复合材料，显示出大大增强的稳定性和独特的pH触发响应。叶绿素，一种模型生物活性物质，首先通过具有高包封效率的共沉淀装载在虫胶纳米颗粒中，然后将装载叶绿素的纳米颗粒掺入从含有纳米颗粒的凝胶介质生长的方解石晶体中。在虫胶纳米颗粒和方解石晶体的保护下，叶绿素即使在光照下也表现出优异的稳定性。只有先在酸性条件下溶解方解石晶体，再在碱性条件下溶解虫胶纳米颗粒，才能释放包裹的叶绿素。独特的pH触发释放模拟pH从胃中的酸性到肠中的碱性的变化，因此非常适合受控的靶向肠释放。这一工作表明，晶体复合材料是一个理想的载体的功能设计的生物活性分子。
Encapsulation of bioactive substances for extended shelf life and controlled, targeted release is critical for their applications in food and drug delivery. Here, a new method has been developed to encapsulate bioactive molecules in the crystal composites, showing greatly enhanced stability and unique pH-triggered response. Chlorophyll, a model bioactive, is first loaded in shellac nanoparticles via co-precipitation with a high encapsulation efficiency, and then the chlorophyll-loaded nanoparticles are incorporated into calcite crystals grown from a gel media containing the nanoparticles. Under the protection of shellac nanoparticles and calcite crystals, chlorophyll shows excellent stability even under light. Encapsulated chlorophyll could only be released by first dissolving the calcite crystals under acidic condition and then dissolving the shellac nanoparticles under alkaline condition. The unique pH-triggered release mimics the pH change from acidic in the stomach to alkaline in the intestine and is thus well suited for controlled, targeted intestinal release. This work suggests that the crystal composites are an ideal delivery vehicle for the functional design of bioactive molecules.