Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
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DOI：
10.1001/archinte.165.7.777
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发表时间：
2005-04-11
影响因子：
--
通讯作者：
Newman, AB
中科院分区：
文献类型：
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作者：
Goodpaster, BH;Krishnaswami, S;Newman, AB
背景资料：代谢综合征是一种包括血脂异常、胰岛素抵抗和高血压的疾病，并且与糖尿病和心血管疾病的风险增加相关。我们确定区域脂肪沉积的模式是否与代谢综合征在老年adults.Methods：一项横断面研究进行，包括一个随机的，基于人口的，符合医疗保险条件的成年人志愿者样本内的一般社区匹兹堡，宾夕法尼亚州和孟菲斯，田纳西州。受试者包括3035名年龄在70至79岁之间的男性和女性，其中41.7%是黑人。代谢综合征的定义采用成人治疗组III标准，包括血清甘油三酯水平、高密度脂蛋白胆固醇水平、血糖水平、血压和腰围。通过计算机断层扫描测量内脏、腹部皮下、肌间和大腿皮下脂肪组织。结果：在正常体重的男性中，内脏脂肪组织与代谢综合征相关（比值比，95%置信区间：2.1，1.6-2.9），超重（1.8，1.5-2.1）和肥胖（1.2，1.0-1.5），以及正常体重（3.3，2.4-4.6），超重（2.4，2.0-3.0）和肥胖（1.7，1.4-2.1）的女性，调整种族。皮下腹部脂肪组织仅与正常体重男性的代谢综合征相关（13，1.1-1.7）。肌间脂肪组织与正常体重（2.3，1.6-3.5）和超重（1.2，1.1-1.4）男性的代谢综合征相关。相反，大腿皮下脂肪组织与肥胖男性（0.9，0.8-1.0）和女性（0.9，0.9-1.0）的代谢综合征呈负相关。结论：除了一般肥胖，身体脂肪的分布是独立相关的代谢综合征在老年男性和女性，特别是在那些正常体重。
Background: The metabolic syndrome is a disorder that includes dyslipidemia, insulin resistance, and hypertension and is associated with an increased risk of diabetes and cardiovascular disease. We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults.Methods: A cross-sectional study was performed that included a random, population-based, volunteer sample of Medicare-eligible adults within the general communities of Pittsburgh, Pa, and Memphis, Tenn. The subjects consisted of 3035 men and women aged 70 to 79 years, of whom 41.7% were black. Metabolic syndrome was defined by Adult Treatment Panel III criteria, including serum triglyceride level, high-density lipoprotein cholesterol level, glucose level, blood pressure, and waist circumference. Visceral, subcutaneous abdominal, intermuscular, and subcutaneous thigh adipose tissue was measured by computed tomography.Results: Visceral adipose tissue was associated with the metabolic syndrome in men who were of normal weight (odds ratio, 95% confidence interval: 2.1, 1.6-2.9), overweight (1.8, 1.5-2.1), and obese (1.2, 1.0-1.5), and in women who were of normal weight (3.3, 2.4-4.6), overweight (2.4, 2.0-3.0), and obese (1.7, 1.4-2.1), adjusting for race. Subcutaneous abdominal adipose tissue was associated with the metabolic syndrome only in normal-weight men (13, 1.1-1.7). Intermuscular adipose tissue was associated with the metabolic syndrome in normal-weight (2.3, 1.6-3.5) and overweight (1.2, 1.1-1.4) men. In contrast, subcutaneous thigh adipose tissue was inversely associated with the metabolic syndrome in obese men (0.9, 0.8-1.0) and women (0.9, 0.9-1.0).Conclusion: In addition to general obesity, the distribution of body fat is independently associated with the metabolic syndrome in older men and women, particularly among those of normal body weight.