Hirsutane Sesquiterpenoids from the Marine-Derived Fungus Chondrostereum sp.
Hirsutane Sesquiterpenoids from the Marine-Derived Fungus Chondrostereum sp.
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来自海洋衍生真菌 Chondrostereum sp 的 Hirsutane 倍半萜类化合物。
DOI：
10.1002/cbdv.201000036
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发表时间：
2011-03-01
影响因子：
2.9
通讯作者：
Zhu, Xiao-Feng
中科院分区：
文献类型：
--
作者：
Li, Hou-Jin;Lan, Wen-Jian;Zhu, Xiao-Feng
从软珊瑚Sarcophyton tortuosum中分离得到一种新的多毛烷倍半萜化合物hirsutanol E(1)，以及已知化合物hirsutanol A(2)和hirsutanol F(3；gleostertriol)。这些化合物的结构主要根据核磁共振、质谱学和X-射线单晶衍射法进行了表征。Hirsutanol A(2)对多种癌细胞具有较强的细胞毒活性。
A new hirsutane sesquiterpenoid, hirsutanol E (1), together with the known compounds hirsutanol A (2) and hirsutanol F (3; gloeosteretriol) were obtained from AcOEt extract of the marine fungus Chondrostereum sp., which was isolated from the soft coral Sarcophyton tortuosum. The structures were elucidated mainly on the basis of the NMR, MS, and X-ray single-crystal diffraction data. Hirsutanol A (2) exhibited potent cytotoxic activities against various cancer cell lines.