The targets of CAPRI rounds 6-12
The targets of CAPRI rounds 6-12
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DOI：
10.1002/prot.21689
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发表时间：
2007-12-01
影响因子：
2.9
通讯作者：
Janin, Jod
中科院分区：
文献类型：
--
作者：
Janin, Jod
在第6-12轮中，晶体学家提供了六种蛋白质-蛋白质复合物和两种参与各种生物过程的同源二聚体蛋白质作为卡普里的目标，卡普里预测组必须通过对接游离蛋白质来预测它们的结构，他们的成功程度在很大程度上取决于构象变化的幅度。至少在一个案例中。该预测指出了复合物晶体中相互作用的其他可能性，表明即使存在实验结构，对接方法也有价值。
Six protein-protein complexes and two homodimeric proteins involved in a variety of biological processes were offered as targets to CAPRI by crystallographers in Rounds 6-12 CAPRI predictor groups had to predict their structure by docking the free proteins, which they did with a degree of success that depended largely on the amplitude of the conformation changes. In one case at least. the prediction pointed to alternative possibilities of interactions in the crystal of a complex, showing that docking methods have value even when there is an experimental structure.