Metabolic gene polymorphism frequencies in control populations.

Metabolic gene polymorphism frequencies in control populations.
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DOI：
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发表时间：
2001-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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通讯作者：
S. Garte;L. Gaspari;A. Alexandrie;C. Ambrosone;H. Autrup;J. Autrup;H. Baranova;L. Bathum;S. Benhamou;P. Boffetta;C. Bouchardy;K. Breskvar;J. Brockmöller;I. Cascorbi;M. Clapper;C. Coutelle;A. Daly;M. Dell'omo;V. Dolžan;C. Dresler;A. Fryer;Aage Haugen;D. Hein;A. Hildesheim;A. Hirvonen;L. Hsieh;M. Ingelman-Sundberg;I. Kalina;D. Kang;M. Kihara;C. Kiyohara;P. Kremers;Phillip Lazarus;L. Marchand;M. Lechner;E. V. Lieshout;S. London;J. Manni;C. Maugard;S. Morita;V. Nazar‐Stewart;K. Noda;Y. Oda;F. Parl;R. Pastorelli;I. Persson;W. Peters;A. Rannug;T. Rebbeck;A. Risch;L. Roelandt;M. Romkes;D. Ryberg;J. Šalagovič;B. Schoket;J. Seidegård;P. Shields;E. Sim;D. Sinnet;Richard C. Strange;I. Stücker;Haruhiko Sugimura;J. To-Figueras;P. Vineis;M. Yu;E. Taioli
S. Garte;L. Gaspari;A. Alexandrie;C. Ambrosone;H. Autrup;J. Autrup;H. Baranova;L. Bathum;S. Benhamou;P. Boffetta;C. Bouchardy;K. Breskvar;J. Brockmöller;I. Cascorbi;M. Clapper;C. Coutelle;A. Daly;M. Dell'omo;V. Dolžan;C. Dresler;A. Fryer;Aage Haugen;D. Hein;A. Hildesheim;A. Hirvonen;L. Hsieh;M. Ingelman-Sundberg;I. Kalina;D. Kang;M. Kihara;C. Kiyohara;P. Kremers;Phillip Lazarus;L. Marchand;M. Lechner;E. V. Lieshout;S. London;J. Manni;C. Maugard;S. Morita;V. Nazar‐Stewart;K. Noda;Y. Oda;F. Parl;R. Pastorelli;I. Persson;W. Peters;A. Rannug;T. Rebbeck;A. Risch;L. Roelandt;M. Romkes;D. Ryberg;J. Šalagovič;B. Schoket;J. Seidegård;P. Shields;E. Sim;D. Sinnet;Richard C. Strange;I. Stücker;Haruhiko Sugimura;J. To-Figueras;P. Vineis;M. Yu;E. Taioli
中科院分区：
其他
文献类型：
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作者：
S. Garte;L. Gaspari;A. Alexandrie;C. Ambrosone;H. Autrup;J. Autrup;H. Baranova;L. Bathum;S. Benhamou;P. Boffetta;C. Bouchardy;K. Breskvar;J. Brockmöller;I. Cascorbi;M. Clapper;C. Coutelle;A. Daly;M. Dell'omo;V. Dolžan;C. Dresler;A. Fryer;Aage Haugen;D. Hein;A. Hildesheim;A. Hirvonen;L. Hsieh;M. Ingelman-Sundberg;I. Kalina;D. Kang;M. Kihara;C. Kiyohara;P. Kremers;Phillip Lazarus;L. Marchand;M. Lechner;E. V. Lieshout;S. London;J. Manni;C. Maugard;S. Morita;V. Nazar‐Stewart;K. Noda;Y. Oda;F. Parl;R. Pastorelli;I. Persson;W. Peters;A. Rannug;T. Rebbeck;A. Risch;L. Roelandt;M. Romkes;D. Ryberg;J. Šalagovič;B. Schoket;J. Seidegård;P. Shields;E. Sim;D. Sinnet;Richard C. Strange;I. Stücker;Haruhiko Sugimura;J. To-Figueras;P. Vineis;M. Yu;E. Taioli

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使用包含超过15，000名对照（非癌症）受试者信息的环境致癌物遗传易感性国际项目（GSEC）数据库，确定了人群中许多更常见的研究代谢基因（CYP1A1，CYP2E1，CYP2D6，GSTM 1，GSTT1，NAT2，GSTP和EPHX）的等位基因和基因型频率。在高加索人（n = 12，525）、亚洲人（n = 2，136）、非洲人和非裔美国人（n = 996）之间观察到这些频率的主要和显著差异，在不同国家的高加索人群中观察到一些但更少的异质性。年龄、性别或对照类型（住院患者与人群对照）的等位基因频率无差异。根据特定等位基因组合的观察频率和预期频率的比较，未检测到不同基因座之间的连锁不平衡。
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.