Amyloids, melanins and oxidative stress in melanomagenesis.
Amyloids, melanins and oxidative stress in melanomagenesis.
复制标题
DOI：
10.1111/exd.12559
复制
发表时间：
2015-03
影响因子：
3.6
通讯作者：
Meyskens FL Jr
中科院分区：
文献类型：
--
作者：
Liu-Smith F;Poe C;Farmer PJ;Meyskens FL Jr
黑色素瘤传统上被认为是紫外线（UV）辐射诱导的恶性肿瘤。虽然紫外线是一个常见的诱导因素，其他内源性应激，如金属离子积累或黑色素本身，可能提供黑色素瘤进展的替代途径。黑色素瘤内的真黑素体通常表现出破坏的膜和破碎的色素，这可能是由于其淀粉样蛋白基纹状体基质的改变。黑素体淀粉样蛋白本身可能是有毒的，特别是与由内源性NADPH氧化酶（NOX）和一氧化氮合酶（NOS）酶产生的活性氧物质（ROS）和活性氮物质（RNS）组合;可能引发黑素瘤形成的有毒混合物。进一步了解黑色素体组织的丧失，暴露的黑色素的行为，以及黑色素瘤中ROS/RNS的诱导，可能会为这种致命疾病提供重要的见解。
Melanoma has traditionally been viewed as an ultra-violet (UV) radiation induced malignancy. While UV is a common inducing factor, other endogenous stresses such as metal ion accumulation or the melanin pigment itself, may provide alternative pathways to melanoma progression. Eumelanosomes within melanoma often exhibit disrupted membranes and fragmented pigment which may be due to alterations in their amyloid-based striatial matrix. The melanosomal amyloid can itself be toxic, especially in combination with reactive oxygen species (ROS) and reactive nitrogen species (RNS) generated by endogenous NADPH oxidase (NOX) and nitric oxide synthase (NOS) enzymes; a toxic mix that may initiate melanomagenesis. Further understanding of the loss of the melanosomal organization, the behavior of the exposed melanin, and the induction of ROS/RNS in melanomas may provide critical insights into this deadly disease.