Serological response and pollovirus excretion following different combined oral and inactivated poliovirus vaccines immunization schedules
Serological response and pollovirus excretion following different combined oral and inactivated poliovirus vaccines immunization schedules
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DOI：
10.1016/s0264-410x(02)00523-6
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发表时间：
2003-04-02
期刊：
影响因子：
5.5
通讯作者：
Mc Cormick, JB
中科院分区：
文献类型：
--
作者：
du Châtelet, IP;Merchant, AT;Mc Cormick, JB
在巴基斯坦卡拉奇进行了一项对照研究，比较根据扩大免疫计划 (EPI) 在出生时以及 6、10 和 14 周时接受口服脊髓灰质炎病毒疫苗 (OPV) 的婴儿与在 6、10 和 14 周同时接受三剂灭活脊髓灰质炎病毒疫苗 (IPV) 的婴儿对脊髓灰质炎病毒的不道德和粘膜免疫反应。 OPV 或在 14 周时与最后一剂 OPV 一起额外注射一剂 IPV。共有1429名婴儿入组； 898 名婴儿 (63%) 获得了 24 周血清样本。他们都在 24 周龄时接受了 3 型 OPV 攻击剂量。与 EP1 方案相比，在三剂 OPV 中添加三剂 IPV 导致 24 周龄时脊髓灰质炎 1 号（97% 对比 89%，P < 0.001）和脊髓灰质炎 3 号（98% 对比 92%）血清反应阳性儿童的比例显着升高。然而，14 周时补充一剂 IPV 并没有增加 24 周时的血清学反应。三组中针对攻击剂量的肠道免疫力相似。以白喉-百日咳-破伤风-IPV 疫苗 (DPT-IPV) 形式的 OPV 和 IPV 联合计划可能有助于加速发展中国家根除脊髓灰质炎。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
A controlled study was conducted in Karachi, Pakistan to compare Immoral and mucosal immune responses against polioviruses in infants who received oral poliovirus vaccine (OPV) at birth and at 6. 10, and 14 weeks according to the Expanded Program on Immunization (EPI) with infants who received either three doses of inactivated poliovirus vaccine (IPV) at 6, 10, and 14 weeks together with OPV or one additional dose of IPV at 14 weeks together, with the last dose of OPV. A total of 1429 infants were enrolled; 24-week serum specimens were available for 898 infants (63%). They all received a challenge dose of OPV type 3 at 24 weeks of age. The addition of three doses of IPV to three doses of OPV induced a significantly higher percentage of seropositive children at 24 weeks of age for polio 1 (97% versus 89%, P < 0.001) and polio 3 (98% versus 92%) compared to the EP1 schedule. However, the one supplemental dose of IPV at 14 weeks did not increase the serological response at 24 weeks. Intestinal immunity against the challenge dose was similar in the three groups. Combined schedules of OPV and IPV in the form of diphtheria-pertussis-tetanus-IPV vaccine (DPT-IPV) may be useful to accelerate eradication of polio in developing countries. (C) 2002 Elsevier Science Ltd. All rights reserved.