Social Instability Stress in Adolescence and Social Interaction in Female Rats
Social Instability Stress in Adolescence and Social Interaction in Female Rats
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DOI：
10.1016/j.neuroscience.2021.09.022
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发表时间：
2021-10-19
期刊：
影响因子：
3.3
通讯作者：
McCormick, Cheryl M.
中科院分区：
文献类型：
--
作者：
Asgari, Pardis;McKinney, Ghraer;McCormick, Cheryl M.
青春期是大脑控制社会行为和社会学习的区域发育的关键时期。社会经历影响神经结构的持续成熟，并最终改变成年人对社会线索的社会行为。与雄性非应激 (CTL) 大鼠相比，青春期的社会不稳定应激（SS；每天 1 小时隔离 + 出生后更换笼内伙伴 [PND] 30-45）导致 SS 大鼠的社交互动长期减少；在这里我们调查女性。在第一个实验中，我们发现暴露于青春期SS的雌性大鼠也表现出社交互动的减少，无论测试的年龄如何，并且复制了之前在雄性大鼠中发现的效果。在仅涉及雌性的实验 2 中，SS 和 CTL 大鼠在高架十字迷宫 (EPM) 中的焦虑样行为没有差异，并且社交互动的减少并不显着。然而，当在青春期 P47（而不是 P71）进行测试时，SS 雌性大鼠在社交互动测试中比 CTL 大鼠具有更高的皮质酮释放，并且通过对 zif268 和 c-fos 的蛋白质产物的免疫反应性测量，它们表现出不同的神经激活模式（内侧前额皮质中 SS < CTL，内侧前额皮质 SS > CTL）。 海马），并且与 CTL 大鼠相比，下丘脑室旁核中催产素免疫反应性降低。这些结果扩展了我们之前关于青春期雌性大鼠 SS 对精神兴奋剂和社会行为的行为反应的影响的发现，并为相关神经机制的研究指明了方向。 (c) 2021 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Adolescence is a critical time of brain development for regions governing social behaviour and social learning. Social experiences influence the ongoing maturation of the neural structures and ultimately modify the social behaviour of adults in response to social cues. Social instability stress in adolescence (SS; daily 1-hour isolation + change of cage partner in postnatal days [PND] 30-45) leads to a long-lasting reduction in social interaction in SS rats compared with non-stressed (CTL) rats in males; here we investigate females. In a first experiment, we found that female rats exposed to adolescent SS also showed the decrement in social interaction irrespective of age at which tested, and replicated the effects previously found in males. In experiment 2, which involved females only, SS and CTL rats did not differ in anxiety-like behaviour in the elevated plus maze (EPM) and the reduction in social interaction was not significant. Nevertheless, when tested in adolescence at P47 (and not at P71), SS female rats had higher corticosterone release during the social interaction test than did CTL rats, and they exhibited a different pattern of neural activation as measured by immunoreactivity to the protein products of zif268 and c-fos (SS < CTL in medial prefrontal cortex and SS > CTL in hippocampus), and reduced oxytocin immunoreactivity in the paraventricular nucleus of the hypothalamus than did CTL rats. These results extend our previous findings of effects of SS in adolescent female rats on behavioural responses to psychostimulants to social behaviour, and point to directions for investigations of the neural mechanisms involved. (c) 2021 IBRO. Published by Elsevier Ltd. All rights reserved.