Activity of oritavancin tested against uncommonly isolated Gram-positive pathogens responsible for documented infections in hospitals worldwide
Activity of oritavancin tested against uncommonly isolated Gram-positive pathogens responsible for documented infections in hospitals worldwide
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DOI：
10.1093/jac/dku016
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发表时间：
2014-06-01
影响因子：
5.2
通讯作者：
Jones, Ronald N.
中科院分区：
文献类型：
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作者：
Mendes, Rodrigo E.;Sader, Helio S.;Jones, Ronald N.
评估奥利万星对2811种罕见凝固酶阴性葡萄球菌（CoNS）、链球菌和其他革兰氏阳性菌种的谱和活性。作为SENTRY计划（2008-12）的一部分，在5年期间共收集了2057种CoNS（14种）、674种链球菌（7组）和80种其他革兰氏阳性菌种（3属）。分离株主要由参与实验室鉴定，并由参考监测实验室（JMI Laboratories，North Liberty，IA，USA）确认。根据CLSI M07-A9和M100-S23文件，通过肉汤微量稀释法检测分离株的敏感性。总体而言，奥利万星对所有CoNS均具有活性（MIC 50/MIC 90，0.015/0.06 mg/L），MIC 50值为千分之一货币符号0.008 -0.03 mg/L。链球菌显示奥利万星MIC 50结果为千分之0.008 mg/L，牛链球菌（0.03 mg/L）、停乳链球菌（0.06 mg/L）和唾液链球菌/前庭链球菌（0.06 mg/L）组除外。微球菌属，单核细胞增生李斯特菌和棒状杆菌属。奥利万星的MIC 50结果为千分之一，货币符号为0.008 mg/L。本研究扩展了奥利万星对几种革兰氏阳性微生物的体外数据。
To assess the oritavancin spectrum and activity against 2811 rarer species of coagulase-negative staphylococci (CoNS), streptococci and other Gram-positive species.A total of 2057 CoNS (14 species), 674 streptococci (7 groups) and 80 other Gram-positive species (3 genera) collected over a 5 year period as part of the SENTRY Program (2008-12) were included. Isolates were primarily identified by the participating laboratory and identification was confirmed by the reference monitoring laboratory (JMI Laboratories, North Liberty, IA, USA). Isolates were tested for susceptibility by broth microdilution following the CLSI M07-A9 and M100-S23 documents.Overall, oritavancin was active against all CoNS (MIC50/MIC90, 0.015/0.06 mg/L), with MIC50 values of a parts per thousand currency sign0.008-0.03 mg/L. Streptococci exhibited oritavancin MIC50 results of a parts per thousand currency sign0.008 mg/L, except for the Streptococcus bovis (0.03 mg/L), Streptococcus dysgalactiae (0.06 mg/L) and Streptococcus salivarius/vestibularis (0.06 mg/L) groups. Micrococcus spp., Listeria monocytogenes and Corynebacterium spp. had oritavancin MIC50 results of a parts per thousand currency sign0.008 mg/L.This study expands the oritavancin in vitro data against several species of Gram-positive organisms.