The Association of Mild, Moderate, and Binge Prenatal Alcohol Exposure and Child Neuropsychological Outcomes: A Meta-Analysis
The Association of Mild, Moderate, and Binge Prenatal Alcohol Exposure and Child Neuropsychological Outcomes: A Meta-Analysis
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DOI：
10.1111/acer.12214
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Cogswell, Mary E.
中科院分区：
文献类型：
--
作者：
Flak, Audrey L.;Su, Su;Cogswell, Mary E.
背景本综述的目的是评估文献的轻度，中度和狂欢产前酒精暴露与儿童神经发育之间的关系。（1970年至2012年8月），EMBASE（1988年至2012年8月）和PsycINFO（（R））（1970年至2012年8月）和检查选定的参考文献。结果从1,593篇文章，我们从队列研究中确定了34个符合我们纳入标准的数据。提取了关于研究人群、结局、测量工具、酒精暴露时间和量化、协变量和结果的信息。结果包括学习成绩、注意力、行为、认知、语言技能、记忆、视觉和运动发育。每篇文章的质量由2名研究人员使用Newcastle-Ottawa量表进行评估。基于对10，000名6个月至14岁儿童的8项研究，我们观察到任何产前酗酒暴露与儿童认知之间存在显著的有害关联（Cohen's d [标准化平均差异得分] -0.13; 95%置信区间[CI]，-0.21，-0.05）。基于对11，900名9个月至5岁儿童的3项高质量研究，我们观察到产前适度饮酒与儿童行为之间存在统计学显著的有害关联（Cohen's d-0.15; 95%CI，-0.28，-0.03）。我们观察到轻度至中度产前酒精暴露与儿童认知之间存在显著（尽管很小）的正相关（Cohen's d 0.04; 95%CI，0.00，0.08），但在事后排除1项评估轻度饮酒的大型研究后，该相关性并不显著，当仅包括评估中度饮酒的研究时，该相关性也不显著。没有其他完成的荟萃分析导致统计学显着关联轻度，中度，或狂欢产前酒精暴露和儿童neuropsychological outcomes.ConclusionsOur研究结果支持以前的研究结果表明，产前酗酒对儿童认知的有害影响。产前酒精暴露水平低于每日饮酒量可能与儿童行为有关。这篇综述的结果强调了在怀孕期间避免酗酒的重要性，并提供了证据表明，怀孕期间没有已知的安全饮酒量。
BackgroundThe objective of this review is to evaluate the literature on the association between mild, moderate, and binge prenatal alcohol exposure and child neurodevelopment.MethodsMeta-analysis with systematic searches of MEDLINE (1970 through August 2012), EMBASE (1988 through August 2012), and PsycINFO((R)) (1970 through August 2012) and examination of selected references.ResultsFrom 1,593 articles, we identified 34 presenting data from cohort studies that met our inclusion criteria. Information on study population, outcomes, measurement instruments, timing and quantification of alcohol exposure, covariates, and results was abstracted. Outcomes included academic performance, attention, behavior, cognition, language skills, memory, and visual and motor development. The quality of each article was assessed by 2 researchers using the Newcastle-Ottawa Scale. Based on 8 studies of 10,000 children aged 6months through 14years, we observed a significant detrimental association between any binge prenatal alcohol exposure and child cognition (Cohen's d [a standardized mean difference score] -0.13; 95% confidence interval [CI], -0.21, -0.05). Based on 3 high-quality studies of 11,900 children aged 9months to 5years, we observed a statistically significant detrimental association between moderate prenatal alcohol exposure and child behavior (Cohen's d -0.15; 95% CI, -0.28, -0.03). We observed a significant, albeit small, positive association between mild-to-moderate prenatal alcohol exposure and child cognition (Cohen's d 0.04; 95% CI, 0.00, 0.08), but the association was not significant after post hoc exclusion of 1 large study that assessed mild consumption nor was it significant when including only studies that assessed moderate alcohol consumption. None of the other completed meta-analyses resulted in statistically significant associations between mild, moderate, or binge prenatal alcohol exposure and child neuropsychological outcomes.ConclusionsOur findings support previous findings suggesting the detrimental effects of prenatal binge drinking on child cognition. Prenatal alcohol exposure at levels less than daily drinking might be detrimentally associated with child behavior. The results of this review highlight the importance of abstaining from binge drinking during pregnancy and provide evidence that there is no known safe amount of alcohol to consume while pregnant.