SYSTEMIC AMYLOIDOSIS AND MALIGNANT DISEASE
SYSTEMIC AMYLOIDOSIS AND MALIGNANT DISEASE
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DOI：
10.1136/jcp.19.6.539
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发表时间：
1966-01-01
影响因子：
3.4
通讯作者：
LEHNER, T
中科院分区：
文献类型：
--
作者：
AZZOPARDI, JG;LEHNER, T
8758例尸检中有93例为系统性淀粉样变。其中14例与恶性有关：与骨髓瘤病或恶性淋巴瘤有关，7例与癌有关。骨髓瘤中淀粉样变的发生率至少为10%。我们注意到肾骨髓瘤管状铸型中淀粉样蛋白的存在。在何杰金氏病中，发病率约为4%，但在接受化疗的患者中可能更高。在淋巴肉瘤中，发病率约为1%的一小部分，但在必需的或与恶性淋巴瘤相关的巨球蛋白血症中，发病率要高得多。系统性淀粉样蛋白见于1 / 375的癌患者，而在1500例“对照病例”中仅见于1例。肾癌占所有系统性淀粉样蛋白相关癌的四分之一。其他癌症起源于不同的器官。在骨髓瘤病中，可在肿瘤沉积物中发现淀粉样蛋白。在何杰金氏病和淋巴肉瘤中，肿瘤组织中的淀粉样蛋白沉积似乎比迄今所认识到的要多。肿瘤提供了淀粉样蛋白与肿瘤的地形关联的一个显著例子，两者在7例中有6例密切相关。
Among 8,758 necropsies there are 93 cases of systemic amyloidosis. Of these 14 are associated with malignancy: with myelomatosis or malignant lymphoma, and 7 with carcinoma. The incidence of amyloidosis in myelomatosis is at least 10%. Attention is drawn to the presence of amyloid in the tubular casts of myeloma kidney''. In Hodgkin''s disease the incidence is about 4% but it may be higher in patients receiving chemotherapy. In lymphosarcoma it is of the order of a fraction of 1% but in marcoglobulinemia, essential or associated with malignant lymphoma, the incidence is considerably higher. Systemic amyloid is found in 1 in 375 of patients with carcinoma and in only a single patient among 1,500 ''control cases''. Renal carcinoma accounts for one-quarter of all carcinomas associated with systemic amyloid. The other carcinomas originate in a variety of organs. In myelomatosis, amyloid may be found in the tumor deposits. In Hodgkin''s disease and in lymphosarcoma there appears to be greater amyloid deposition in neoplastic tissue than hitherto realized. The carcinomas provide a striking example of topographical association of amyloid and tumor, the 2 being closely related in 6 of 7 cases.