Perspectives on glucocorticoid-induced osteoporosis
Perspectives on glucocorticoid-induced osteoporosis
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DOI：
10.1016/j.bone.2003.11.026
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发表时间：
2004-04-01
期刊：
影响因子：
4.1
通讯作者：
Giustina, A
中科院分区：
文献类型：
--
作者：
Canalis, E;Bilezikian, JP;Giustina, A
糖皮质激素诱导的骨质疏松症（GIO）是继发性骨质疏松症最常见的原因，是糖皮质激素对骨骼产生深远影响的结果。这篇文章是对细胞和临床水平的新发现的观点，因为它们与GIO有关。概述的一些概念来自于2003年3月在意大利都灵举行的第三届GIO国际大会上的精选演讲。糖皮质激素对骨骼代谢的全身作用与其对骨骼的最终作用有关。然而，最近，我们的注意力集中在这些类固醇对骨骼细胞的直接作用上。骨是由并列的破骨细胞和成骨细胞组成的基本多细胞单位不断重塑的。由全身或局部因素引起的细胞数量或功能的改变可导致骨骼稳态失衡，最终导致骨质流失。糖皮质激素对骨细胞有直接影响，导致细胞数量和功能的改变，从而导致骨质流失。
Glucocorticoid-induced osteoporosis (GIO) is the most common cause of secondary osteoporosis and is the result of the profound effects of glucocorticoids on the skeleton. This article is a perspective on new discoveries at the cellular and clinical level as they relate to GIO. Some of the concepts outlined are derived from selected presentations made at the 3rd International Congress on GIO held in Turin, Italy, in March 2003.The systemic effects of glucocorticoids on skeletal metabolism are relevant to their ultimate effects on the skeleton. However, recently, our attention has focused on the direct actions of these steroids on skeletal cells. Bone is continuously remodeled by basic multicellular units composed of teams of juxtaposed osteoclasts and osteoblasts. Alterations in the number of cells or in their function by systemic or local agents can lead to an imbalance in skeletal homeostasis and eventually to bone loss. Glucocorticoids have direct effects in bone cells leading to changes in cell number and function that in the aggregate account for bone loss.