Stereocontrolled Syntheses of Carotenoid Oxidative Metabolites, (−)-Loliolide, (−)-Xanthoxin, and Their Stereoisomers
Stereocontrolled Syntheses of Carotenoid Oxidative Metabolites, (−)-Loliolide, (−)-Xanthoxin, and Their Stereoisomers
复制标题
类胡萝卜素氧化代谢物、(−)-Loliolide、(−)-Xanthoxin 及其立体异构体的立体控制合成
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
S. Katsumura
中科院分区：
文献类型：
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作者：
M. Kuba;Noriyuki Furuichi;S. Katsumura
我们分别以（+）-或（-）-3-烷氧基-6-羟甲基-1，1，5-三甲基环己烯为起始原料，通过高非对映选择性的Sharpless不对称环氧化反应或mCPBA氧化反应合成了相应的顺式和反式环氧化物，实现了（-）-萝芙木、（-）-黄嘌呤及其立体异构体的立体控制合成。
We achieved the stereocontrolled syntheses of (−)-loliolide, (−)-xanthoxin, and their stereoisomers from (+)- or (−)-3-alkoxy-6-hydroxymethyl-1,1,5-trimethylcyclohexene through the corresponding syn and anti-epoxides, respectively, which were obtained by utilizing the highly diastereoselective Sharpless asymmetric epoxidation or mCPBA oxidation.