TREATMENT OF CHRONIC GRANULOCYTIC-LEUKEMIA WITH CHEMORADIOTHERAPY AND TRANSPLANTATION OF MARROW FROM IDENTICAL-TWINS
TREATMENT OF CHRONIC GRANULOCYTIC-LEUKEMIA WITH CHEMORADIOTHERAPY AND TRANSPLANTATION OF MARROW FROM IDENTICAL-TWINS
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DOI：
10.1056/nejm198201143060202
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
THOMAS, ED
中科院分区：
文献类型：
--
作者：
FEFER, A;CHEEVER, MA;THOMAS, ED
Twelve patients in the chronic phase of Ph1 (Philadelphia chromosome)-positive chronic granulocytic leukemia (CGL) received chemoradiotherapy and marrow from their normal, identical twins. All had a complete remission, with disappearance of all Ph1-positive cells. One patient died of pneumonitis while in remission. Three had a cytogenetic relapse 22-30 mo. after grafting; only 1 of these 3 entered blast crisis and died. Eight remain in complete remission 21-65 mo. (median, 30 mo.) after transplantation. Thus, the Ph1-positive clone can be ablated and blast crisis delayed or prevented. Of 10 patients with CGL who received transplants during the terminal phase, 8 died soon after, 1 is in complete remission 11 mo. after receiving a 2nd graft, and 1 remains in complete remission 71 mo. after transplantation. Every patient with CGL and an identical twin probably should receive a marrow graft, preferably in the chronic phase. Trials of allogeneic-marrow transplantation for CGL seem justified.
