Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc
Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc
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DOI：
10.1007/s10528-017-9791-z
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发表时间：
2017-06-01
影响因子：
2.4
通讯作者：
Mogulkoc, Rasim
中科院分区：
文献类型：
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作者：
Baltaci, Abdulkerim Kasim;Mogulkoc, Rasim
由于锌介导许多激素的作用或存在于许多激素受体的结构中，锌缺乏导致激素平衡中的各种功能障碍。甲状腺激素对新陈代谢和进食也有重要作用。NPY和瘦素对食物摄入和食欲调节有影响。本研究旨在确定补锌和缺锌对甲状腺功能障碍大鼠甲状腺激素（游离和总T3和T4）、褪黑素、瘦素和NPY水平的影响。本研究各试验组分为：对照组(C)；甲状腺功能减退(PTU);甲状腺功能减退+锌(PTU +锌);甲状腺功能减退+锌缺陷;甲状腺机能亢进(H);甲状腺机能亢进+锌(H +锌);甲状腺机能亢进+锌缺乏甲状腺激素参数（FT3、FT4、TT3和TT4）在甲状腺功能减退组降低，在甲状腺功能亢进组升高。褪黑素值在甲状腺功能亢进症中升高，在甲状腺功能减退症中降低。瘦素和NPY水平在甲亢和甲亢时均升高。另一方面，锌水平在甲状腺功能减退症中下降，在甲状腺功能亢进症中增加。补充锌，特别是当甲状腺功能受损时，已被证明可以显著预防这些变化。
Since zinc mediates the effects of many hormones or is found in the structure of numerous hormone receptors, zinc deficiency leads to various functional impairments in the hormone balance. And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite. The present study is conducted to determine how zinc supplementation and deficiency affect thyroid hormones (free and total T3 and T4), melatonin, leptin, and NPY levels in thyroid dysfunction in rats. The experiment groups in the study were formed as follows: Control (C); Hypothyroidism (PTU); Hypothyroidism+Zinc (PTU+Zn); Hypothyroidism+Zinc deficient; Hyperthyroidism (H); Hyperthyroidism+Zinc (H+Zn); and Hyperthyroidism+Zinc deficient. Thyroid hormone parameters (FT3, FT4, TT3, and TT4) were found to be reduced in hypothyroidism groups and elevated in the hyperthyroidism groups. Melatonin values increased in hyperthyroidism and decreased in hypothyroidism. Leptin and NPY levels both increased in hypo- and hyperthyroidism. Zinc levels, on the other hand, decreased in hypothyroidism and increased in hyperthyroidism. Zinc supplementation, particularly when thyroid function is impaired, has been demonstrated to markedly prevent these changes.