Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
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DOI：
10.1016/s0962-8924(98)01359-2
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发表时间：
1998-10-01
影响因子：
19
通讯作者：
Gherardi, E
中科院分区：
文献类型：
--
作者：
Birchmeier, C;Gherardi, E
许多涉及细胞迁移、生长或形态形成的发育过程依赖于细胞外信号。肝细胞生长因子/分散因子(HGF/SF)是一种提供这类信号的分子，由于其独特的结构、激活机制和在胚胎发育过程中的重要作用，近年来引起了人们的极大兴趣。本文就c-met原癌基因产物HGF/SF及其受体的主要特征及其在胚胎发生中的作用作一综述。
A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.