Bone and skeletal muscle: neighbors with close ties.
Bone and skeletal muscle: neighbors with close ties.
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DOI：
10.1002/jbmr.1969
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Esser KA
中科院分区：
文献类型：
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作者：
DiGirolamo DJ;Kiel DP;Esser KA
肌肉骨骼系统在哺乳动物中进化，以执行各种功能，包括运动，促进呼吸，保护内部器官和协调全球能量消耗。参与运动的骨骼和骨骼肌都来源于体节中胚层，并根据遗传信息和环境刺激同步积累峰值组织质量。衰老导致骨（骨质减少）和骨骼肌（肌肉减少）的进行性和平行损失，对生活质量产生深远影响。骨骼肌相关的肌肉减少症导致耐力降低、平衡性差和活动性降低，使老年个体易于福尔斯跌倒，由于伴随的骨质疏松症，跌倒更频繁地导致骨折。因此，更好地了解这些组织的平行发育和退化的机制对于开发新的和更有效的方法来对抗我们日益老龄化的人口中的骨质疏松症和肌肉减少症至关重要。这一观点强调了我们对骨和骨骼肌质量耦合机制的理解的最新进展，并确定了需要进一步工作的关键领域。
The musculoskeletal system evolved in mammals to perform diverse functions that include locomotion, facilitating breathing, protecting internal organs, and coordinating global energy expenditure. Bone and skeletal muscles involved with locomotion are both derived from somitic mesoderm and accumulate peak tissue mass synchronously, according to genetic information and environmental stimuli. Aging results in the progressive and parallel loss of bone (osteopenia) and skeletal muscle (sarcopenia) with profound consequences for quality of life. Age-associated sarcopenia results in reduced endurance, poor balance, and reduced mobility that predispose elderly individuals to falls, which more frequently result in fracture because of concomitant osteoporosis. Thus, a better understanding of the mechanisms underlying the parallel development and involution of these tissues is critical to developing new and more effective means to combat osteoporosis and sarcopenia in our increasingly aged population. This perspective highlights recent advances in our understanding of mechanisms coupling bone and skeletal muscle mass, and identify critical areas where further work is needed.