Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation
Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation
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DOI：
10.1111/j.1460-9568.2004.03652.x
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发表时间：
2004-10-01
影响因子：
3.4
通讯作者：
Fink, DJ
中科院分区：
文献类型：
--
作者：
Hu, J;Mata, M;Fink, DJ
部分神经损伤导致难以有效治疗的慢性疼痛。为了研究这一现象的解剖学基础，我们用麦胚凝集素-辣根过氧化物酶（WGA-HRP）标记的未受伤的小纤维（Δ和C）在一个良好的模型，神经性疼痛的选择性脊神经结扎在成人的中央投影。我们发现广泛的发芽未受伤的WGA-HRP标记的传入神经进入中央终止领域在板II的背角通常被L5传入神经，其外周轴突已被结扎远端的背根神经节。在成年人中，未受伤的纤维形成新的投射到功能上而非解剖学上的去传入区可能在慢性疼痛的发展中起作用。
Partial nerve injury results in chronic pain that is difficult to treat effectively. To investigate the anatomic basis of this phenomenon we used wheat germ agglutinin-horseradish peroxidase (WGA-HRP) to label the central projections of uninjured small fibers (Adelta and C) in a well-established model of neuropathic pain created by selective spinal nerve ligation in the adult. We found extensive sprouting of uninjured WGA-HRP-labeled afferents into the central termination field in lamina II of dorsal horn normally occupied by L5 afferents whose peripheral axons had been ligated distal to the dorsal root ganglion. The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain.