Effect of epidermal acylglucosylceramides and acylceramides on the morphology of liposomes prepared from stratum corneum lipids.
Effect of epidermal acylglucosylceramides and acylceramides on the morphology of liposomes prepared from stratum corneum lipids.
复制标题
表皮酰基葡萄糖神经酰胺和酰基神经酰胺对角质层脂质制备的脂质体形态的影响。
DOI：
10.1016/0005-2736(88)90086-7
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Downing,DT
中科院分区：
文献类型：
--
作者：
Abraham,W;Wertz,PW;Downing,DT
表皮酰基葡萄糖神经酰胺（AGC）和酰基神经酰胺（AC）引起角质层脂质脂质体的聚集和堆积，该脂质体由含有表皮神经酰胺（40％）、胆固醇（25％）、棕榈酸（25％）和硫酸胆固醇（10％）的脂质混合物形成。这证明了这些鞘脂将相邻双层保持紧密并列的能力及其在表皮层状结构组装中的作用。然而，氢化形式的AGC和AC也会引起角质层脂质脂质体的聚集和堆积。这使人们对亚油酸酯在 AGC 和 AC 分别作为表皮层状颗粒和角质层细胞间层状组装中的分子铆钉的功能中的结构特异性产生了疑问。
Epidermal acylglucosylceramides (AGC) and acylceramides (AC) cause aggregation and stacking of stratum corneum lipid liposomes formed from a lipid mixture containing epidermal ceramides (40%), cholesterol (25%), palmitic acid (25%), and cholesteryl sulfate (10%). This demonstrates the ability of these sphingolipids to hold adjacent bilayers in close apposition and their roles in the assembly of lamellar structures in the epidermis. However, AGC and AC in their hydrogenated form also caused aggregation and stacking of the stratum corneum lipid liposomes. This throws into doubt the proposed structural specificity of linoleate in the function of AGC and AC as molecular rivets in the assembly of the epidermal lamellar granules and the stratum corneum intercellular lamellae, respectively.