Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites.
Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites.
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原人参二醇和原人参三醇型人参皂苷及其代谢物的抗癌活性
DOI：
10.1155/2016/5738694
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Gao JL
中科院分区：
文献类型：
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作者：
Chen XJ;Zhang XJ;Shui YM;Wan JB;Gao JL
近年来，大多数抗癌药物都来自于天然资源，如海洋，微生物和植物来源，但化疗的低成功率和多药耐药性的发展强调了发现新化合物的重要性，这些化合物既安全又有效。人参类型，包括亚洲人参，西洋参和三七，由于其免疫调节，神经保护，抗氧化和抗肿瘤活性，传统上用于治疗各种疾病。人参皂苷作为人参的主要活性成分，对肿瘤的治疗作用已被越来越多的研究报道。20（S）-原人参二醇组（PDS）和20（S）-原人参三醇组皂苷（PTS）是人参皂苷中两种特征性的三萜皂苷。PTS具有干扰关键代谢的能力，而PDS可以影响细胞周期分布和促死亡信号。本文综述了PTS和PDS及其代谢产物的不同抗癌作用，并提出这些化合物可能是目前抗癌化疗策略的有效补充。
Recently, most anticancer drugs are derived from natural resources such as marine, microbial, and botanical sources, but the low success rates of chemotherapies and the development of multidrug resistance emphasize the importance of discovering new compounds that are both safe and effective against cancer. Ginseng types, including Asian ginseng, American ginseng, and notoginseng, have been used traditionally to treat various diseases, due to their immunomodulatory, neuroprotective, antioxidative, and antitumor activities. Accumulating reports have shown that ginsenosides, the major active component of ginseng, were helpful for tumor treatment. 20(S)-Protopanaxadiol (PDS) and 20(S)-protopanaxatriol saponins (PTS) are two characteristic types of triterpenoid saponins in ginsenosides. PTS holds capacity to interfere with crucial metabolism, while PDS could affect cell cycle distribution and prodeath signaling. This review aims at providing an overview of PTS and PDS, as well as their metabolites, regarding their different anticancer effects with the proposal that these compounds might be potent additions to the current chemotherapeutic strategy against cancer.