A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity
A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity
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DOI：
10.1126/science.273.5280.1402
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发表时间：
1996-09-06
期刊：
影响因子：
56.9
通讯作者：
Schuman, EM
中科院分区：
文献类型：
--
作者：
Kang, HJ;Schuman, EM
两种神经营养因子，脑源性神经营养因子 (BDNF) 和神经营养蛋白-3 (NT-3)，能够持久增强海马突触传递。与其他形式的可塑性不同，神经营养素诱导的可塑性表现出对蛋白质合成的直接需求。突触神经纤维与主细胞体分离的大鼠海马切片的可塑性也需要早期蛋白质合成。因此，神经营养蛋白可以刺激轴突或树突区室中蛋白质的合成，从而允许突触对各个突触位点表达的蛋白质补体进行局部控制。
Two neurotrophic factors,brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate the synthesis of proteins in either axonal or dendritic compartments, allowing synapses to exert local control over the complement of proteins expressed at individual synaptic sites.