Characterization of Monoclonal Antibodies against Hokkaido Strain Tick‐Borne Encephalitis Virus
Characterization of Monoclonal Antibodies against Hokkaido Strain Tick‐Borne Encephalitis Virus
复制标题
抗北海道株蜱传脑炎病毒单克隆抗体的表征
DOI：
10.1111/j.1348-0421.2000.tb02530.x
复制
发表时间：
2000
影响因子：
2.6
通讯作者：
I. Takashima
中科院分区：
文献类型：
--
作者：
K. Komoro;D. Hayasaka;T. Mizutani;H. Kariwa;I. Takashima
1993年在北海道发现了一名蜱传脑炎（TBE）患者，我们在以前的研究中从动物和蜱中分离出TBE病毒。为了开发鉴定TBE病毒的诊断试剂，制备了抗TBE病毒株北海道（Oshima 5-10）的单克隆抗体（Mab）。获得了与Oshima 5-10菌株的包膜蛋白反应的7个单克隆抗体。这些单克隆抗体具有黄病毒属特异性、TBE病毒复合物特异性或TBE病毒类型特异性。单克隆抗体适用于TBE病毒株的鉴定。
A tick‐borne encephalitis (TBE) patient was found in Hokkaido in 1993, and TBE viruses were isolated from animals and ticks in our previous studies. To develop a diagnostic reagent to identify TBE viruses, monoclonal antibodies (Mabs) were produced against the TBE virus strain Hokkaido (Oshima 5–10). Seven Mabs were obtained which reacted with the envelope protein of the Oshima 5–10 strain. These Mabs were flavivirus genus‐specific, TBE virus complex‐specific or TBE virus type‐specific. The Mabs are applicable for identification of TBE virus strains.