Kinetics of phospholipid exchange between bilayer membranes.
Kinetics of phospholipid exchange between bilayer membranes.
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双层膜之间磷脂交换的动力学。
DOI：
10.1016/0005-2736(77)90168-7
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
L. Thilo
中科院分区：
文献类型：
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作者：
L. Thilo
在Duckwitz-Peterlein、Eilenberger和奥弗拉特（（1977）Biochim. Biophys. Acta 469，311-325）显示，由来自大肠杆菌的总磷脂提取物组成的带负电荷的囊泡之间的脂质分子交换通过单个脂质单体或小胶束通过水的转移而发生。这里的动力学解释是提出的速率常数，k-，为逃逸的脂质分子从囊泡双层进入水中。对于以反式-Δ 9-十六碳烯酸和反式-Δ 9-十八碳烯酸为主要酰基链组分的磷脂分子，估算的速率常数分别为k-P =（0.86±0.05）· 10− 5 s− 1和k-E =（1.09±0.13）· 10− 6 s− 1。的速率常数进行了讨论的酰基链和极性头基组成的脂质。
In an accompanying publication by Duckwitz-Peterlein, Eilenberger and Overath ((1977) Biochim. Biophys. Acta 469, 311–325) it is shown that the exchange of lipid molecules between negatively charged vesicles consisting of total phospholipid extracts from Escherichia coli occurs by the transfer of single lipid monomers or small micelles through the water. Here a kinetic interpretation is presented in terms of a rate constant, k−, for the escape of lipid molecules from the vesicle bilayer into the water. The evaluated rate constants are k− P=(0.86±0.05)· 10− 5 s− 1 and k− E=(1.09±0.13)· 10− 6 s− 1 for phospholipid molecules with trans-Δ 9-hexadecenoate and trans-Δ 9-octadecenoate, respectively, as the predominant acyl chain component. The rate constants are discussed in terms of the acyl chain and polar head group composition of the lipids.