Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
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DOI：
10.1016/s0197-4580(00)00149-4
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发表时间：
2000-09-01
影响因子：
4.2
通讯作者：
Rinne, JO
中科院分区：
文献类型：
--
作者：
Kaasinen, V;Vilkman, H;Rinne, JO
纹状体中多巴胺D2样受体的缺失与人类的正常衰老以及老年人的认知和运动功能受损有关。为探讨纹状体外多巴胺D2和D3受体亚型(D2/3Rs)是否存在年龄相关性变化，应用D2/3R选择性高亲和力放射性配基[C-11]FLB457对24例正常男性(年龄19~74岁)进行正电子发射断层扫描(PET)检查。在所有被研究的脑区中，D2/3Rs显著地随年龄的增长而下降：前扣带回皮质(每十年增长13%，P<；0.001)，额叶皮质(11%，P<；0.001)，外侧颞叶皮质(10%，P<；0.001)，海马体(10%，P<；0.01)，内侧颞叶皮质(9%，P<；0.001)，杏仁核(7%，P<；0.001)；内侧丘脑(6%，P&0.001)和外侧丘脑(5%，P&t；0.01)。额叶皮质D2/3R下降的速度明显快于内侧颞叶皮质(P<；0.05，Bonferroni校正)和丘脑内侧(P<；0.05，Bonferroni校正)。这些结果表明，先前证实的与年龄相关的纹状体多巴胺D2受体的下降延伸到正常男性的纹状体外的几个区域。此外，与颞区和丘脑区相比，额叶皮质D2/3R下降的速度可能更快。(C)2000 Elsevier Science Inc.保留所有权利。
Loss of dopamine D2-like receptors in the striatum has been associated with both normal human aging and impairment of cognitive and motor functions in the elderly. To investigate whether there are age-associated changes in dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the striatum, a D2/3R selective high-affinity radioligand [C-11]FLB 457 was used in positron emission tomography (PET) examinations for 24 normal healthy male subjects (age range 19-74 years). Significant age-related declines of D2/3Rs were detected in all the brain regions studied: the anterior cingulate cortex (decline of 13% per increase of a decade in age, P < 0.001), the frontal cortex (11%, P < 0.001), the lateral temporal cortex (10%, P < 0.001), the hippocampus (10%, P < 0.01), the medial temporal cortex (9%, P < 0.001), the amygdala (7%, P < 0,01), the medial thalamus (6%, P < 0.001) and the lateral thalamus (5%, P < 0.01). The rate of D2/3R decline was significantly faster in the frontal cortex as compared to the medial temporal cortex (P < 0.05, Bonferroni corrected) and as compared to the medial thalamus (P < 0.05, Bonferroni corrected). These results indicate that the previously demonstrated age-related decline in striatal dopamine D2 receptors extends to several extrastriatal regions in normal human males. Further, the rate of D2/3R decline may be faster in the frontal cortex as compared to the temporal and thalamic regions. (C) 2000 Elsevier Science Inc. All rights reserved.