R5 HIV env and vesicular stomatitis virus G protein cooperate to mediate fusion to naive CD4+ T Cells.
R5 HIV env and vesicular stomatitis virus G protein cooperate to mediate fusion to naive CD4+ T Cells.
复制标题
R5 HIV env 和水疱性口炎病毒 G 蛋白协同介导与初始 CD4 T 细胞的融合。
DOI：
10.1128/jvi.01851-10
复制
发表时间：
2011
影响因子：
5.4
通讯作者：
O'Doherty,Una
中科院分区：
文献类型：
--
作者：
Pace,MatthewJ;Agosto,Luis;O'Doherty,Una
Naïve CD44T cells are resistant to both HIV R5envand vesicular stomatitis virus G protein (VSV-G)-mediated fusion. However, viral particles carrying both HIV R5envand VSV-G infect naïve cells by an unexplained mechanism. We show that VSV-G-pseudotyped virus cannot fuse to unstimulated cells because the viral particles cannot be endocytosed. However, virions carrying both HIV R5envand VSV-G can fuse because CD4 binding allows viral uptake. Our findings reveal a unique mechanism by which R5 HIVenvand VSV-G cooperate to allow entry to naïve CD4+T cells, providing a tool to target naïve CD4+T cells with R5 HIV to study HIV coreceptor signaling and latency.
