Myelopathy due to copper deficiency following gastrointestinal surgery
Myelopathy due to copper deficiency following gastrointestinal surgery
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DOI：
10.1001/archneur.60.12.1782
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发表时间：
2003-12-01
影响因子：
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通讯作者：
Ahlskog, JE
中科院分区：
文献类型：
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作者：
Kumar, N;McEvoy, KM;Ahlskog, JE
背景：由于铜缺乏引起的共济失调性脊髓病已在反刍动物中被描述，并被称为swayback。由于遗传性铜缺乏继发于肠道铜吸收失败的神经系统表现被公认为门克斯病。获得性铜缺乏症在人类的神经系统的后果是没有很好的described.Objective：报告2例患者开发了脊髓病与铜缺乏后胃肠surgery.Patients：两名患者开发了脊髓病多年后胃肠手术。两人都有严重的铜缺乏症，这是脊髓病的可能原因。结论：获得性铜缺乏症可能会出现脊髓病。胃肠道手术和由此导致的铜吸收减少可能是病因。
Background: Ataxic myelopathy due to copper deficiency has been described in ruminant animals and is called swayback. Neurological manifestations due to inherited copper deficiency secondary to the failure of intestinal copper absorption is well recognized as Menkes disease. The neurological consequences of acquired copper deficiency in humans are not well described.Objective: To report 2 cases where patients developed a myelopathy with copper deficiency after gastrointestinal surgery.Patients: Two patients developed a myelopathy many years after gastrointestinal surgery. Both had severe copper deficiency, which was the likely cause of the myelopathy.Conclusions: Acquired copper deficiency may present as a myelopathy. Gastrointestinal surgery and resulting decreased copper absorption may be causative.