CHEMOPREVENTION OF NEONATAL JAUNDICE - POTENCY OF TIN-PROTOPORPHYRIN IN AN ANIMAL-MODEL
CHEMOPREVENTION OF NEONATAL JAUNDICE - POTENCY OF TIN-PROTOPORPHYRIN IN AN ANIMAL-MODEL
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DOI：
10.1126/science.6896768
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
KAPPAS, A
中科院分区：
文献类型：
--
作者：
DRUMMOND, GS;KAPPAS, A
通过单次施用锡-原卟啉（10 μ mol/kg体重）防止新生大鼠出生后不久发生的肝、脾和肾血红素加氧酶水平的显著增加。通过这种治疗，血清胆红素水平在24小时内下降至接近正常的成人水平，并在整个产后期间保持较低水平。锌原卟啉的剂量高达50倍以上的有效剂量的锡原卟啉没有防止立即增加组织血红素加氧酶的活动和血清胆红素水平发生产后。在体外研究与微粒体血红素加氧酶在人脾脏表明，锡原卟啉是一个有效的竞争性抑制剂血红素氧化胆色素在这个组织。
The substantial increases of hepatic, splenic and renal heme oxygenase levels that occur shortly after birth in neonatal rats were prevented by a single administration of tin-protoporphyrin (10 .mu.mol/kg of body wt). With this treatment serum bilirubin levels declined within 24 h to near-normal adult levels and remained low throughout the postnatal period. Zinc-protoporphyrin at doses up to 50-fold greater than the effective dose of tin-protoporphyrin did not prevent the immediate increases in tissue heme oxygenase activities and in serum bilirubin levels that occur postnatally. Studies in vitro with microsomal heme oxygenase in human spleen indicate that tin-protoporphyrin is a potent competitive inhibitor of the oxidation of heme to bile pigment in this tissue.