Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy
Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy
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DOI：
10.1016/j.envres.2011.01.021
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发表时间：
2011-05-01
影响因子：
8.3
通讯作者：
Kishi, Reiko
中科院分区：
文献类型：
--
作者：
Miyashita, Chihiro;Sasaki, Seiko;Kishi, Reiko
二恶英类化合物是内分泌干扰物。出生前暴露于环境水平的二恶英对婴儿期免疫功能的影响尚不清楚，尽管二恶英会导致动物后代的免疫抑制。此外，人类研究还没有评估性别或同类差异的影响。这项研究的目的是调查母体血液中的二恶英水平与婴儿感染和过敏的风险之间的关系。我们调查了2002年至2005年在日本札幌参加北海道环境与儿童健康研究的364名母亲和她们的婴儿。相关信息是从怀孕期间的基线调查问卷、分娩时的医疗记录以及孩子18个月大时评估婴儿过敏和感染发展情况的跟踪调查问卷中收集的。用高分辨气相色谱/高分辨质谱仪测定母血中二恶英类化合物的含量。相对较高的多氯二苯并呋喃水平与中耳炎风险显著增加相关，特别是在男婴中(优势比=2.5，95%可信区间=1.1-5.9)。相对较高的2，3，4，7，8-五氯二苯并呋喃水平也与患中耳炎的风险显著增加相关(优势比=5.3，95%可信区间=1.5-19)。然而，我们观察到二恶英类化合物水平与婴儿期过敏症状之间存在微弱的相关性。在环境层面上，产前接触二恶英类化合物可能会改变免疫功能，增加婴儿时期感染的风险，特别是在男性中。化合物2，3，4，7，8-五氯二苯并呋喃可能与此有关。(C)2011 Elsevier Inc.保留所有权利。
Dioxin-like compounds are endocrine disruptors. The effects of prenatal exposure to environmental levels of dioxins on immune function during infancy have not been clarified, although dioxins induce immunosuppression in offspring of animals. Moreover, human studies have not assessed the effects of gender- or congener-specific differences. The purpose of this study was to investigate the association between dioxin levels in maternal blood and the risk of infection and allergies in infancy. We examined 364 mothers and their infants enrolled in a Hokkaido Study on Environment and Children's Health between 2002 and 2005 in Sapporo, Japan. Relevant information was collected from a baseline questionnaire during pregnancy, medical records at delivery, and a follow-up questionnaire when the child was 18 months of age that assessed development of allergies and infections in infancy. Dioxin-like compound levels in maternal blood were measured with high-resolution gas chromatography/high-resolution mass spectrometry. Relatively higher levels of polychlorinated dibenzofuran were associated with a significantly increased risk of otitis media, especially among male infants (odds ratio=2.5, 95% confidence interval=1.1-5.9). Relatively higher levels of 2,3,4,7,8-pentachlorodibenzofuran were also associated with a significantly increased risk of otitis media (odds ratio=5.3, 95% confidence interval=1.5-19). However, we observed a weak association between dioxin-like compound levels and allergic symptoms in infancy. At environmental levels, prenatal exposure to dioxin-like compounds may alter immune function and increase the risk of infections in infancy, especially among males. The compound 2,3,4,7,8-pentachlorodibenzofuran may be responsible for this. (c) 2011 Elsevier Inc. All rights reserved.