Labrenzbactin from a coral-associated bacterium Labrenzia sp.
Labrenzbactin from a coral-associated bacterium Labrenzia sp.
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DOI：
10.1038/s41429-019-0192-x
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发表时间：
2019-08-01
影响因子：
3.3
通讯作者：
Igarashi, Yasuhiro
中科院分区：
文献类型：
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作者：
Sharma, Amit Raj;Zhou, Tao;Igarashi, Yasuhiro
从珊瑚伴生菌Labrenzia sp发酵液中分离到一种新的含儿茶酚酸的铁载体labrenzbactin(1)，并通过波谱法和Marfey分析确定了其结构和绝对构型。总体而言，1对茄枯菌SUPP1541和黄体微球菌ATCC9341具有抗菌活性，MIC值分别为25和50 μ g ml(-1)，对P388小鼠白血病细胞具有细胞毒性，IC50值为13 μ M。
A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey's analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 mu g ml(-1), respectively, and cytotoxicity against P388 murine leukemia cells with an IC50 of 13 mu M.