Age-related cortical thinning in schizophrenia
Age-related cortical thinning in schizophrenia
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DOI：
10.1016/j.schres.2010.10.004
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发表时间：
2011-01-01
影响因子：
4.5
通讯作者：
Murai, Toshiya
中科院分区：
文献类型：
--
作者：
Kubota, Manabu;Miyata, Jun;Murai, Toshiya
尽管衰老对精神分裂症神经相关因素的影响已经研究多年，但尚未得出明确的结论。虽然一些研究表明，精神分裂症患者与年龄相关的灰质逐渐减少，但其他研究没有发现进展的证据。此外，尚不清楚衰老对精神分裂症患者和健康对照者的整体或区域皮质厚度的影响是否不同。本研究旨在证实先前关于精神分裂症患者皮质厚度减少的报道，并探讨年龄对整体和区域皮质厚度的影响。83名精神分裂症患者（6名首发患者和77名慢性患者，年龄范围为18-55岁）和90名年龄、性别和教育程度相匹配的健康对照（年龄范围为19-56岁）使用3-Tesla扫描仪进行了结构磁共振成像（MRI）。采用基于表面的分析评估全脑皮质厚度。患者组在包括前额叶和颞叶皮质在内的区域均表现出整体和局部皮质变薄。在患者和对照组中，年龄和皮质厚度之间的相关性在全球和区域上都显示出相似的模式。这些结果表明，精神分裂症患者皮质厚度的减少可能不会在疾病过程中渐进式发生，这表明病理过程发生在发病前后相对有限的时间内。(C) 2010 Elsevier B.V.版权所有
Although the effects of aging on the neural correlates of schizophrenia have been researched for many years, no clear conclusion has been reached. While some studies have demonstrated progressive age-related gray matter reductions in schizophrenia, other studies have not found evidence of progression. Moreover, it remains unclear whether the influence of aging on global or regional cortical thickness differs between schizophrenia patients and healthy controls. This study aimed to confirm previous reports of reduced cortical thickness in schizophrenia, and to investigate the effects of age on global and regional cortical thickness. Eighty-three patients with schizophrenia (six first-episode patients and 77 chronic patients; age range = 18-55 years) and 90 age-, gender- and education-matched healthy controls (age range = 19-56 years) underwent structural magnetic resonance imaging (MRI) using a 3-Tesla scanner. Surface-based analysis was applied to assess cortical thickness in the whole brain. The patient group exhibited both global and regional cortical thinning in regions including the prefrontal and temporal cortices. The correlation between age and cortical thickness showed a similar pattern in patients and controls, both globally and regionally. These results suggest that the reduction of cortical thickness in schizophrenia might not be progressive over the course of the illness, indicating that pathological processes occur in a relatively limited period of time around the onset of illness. (C) 2010 Elsevier B.V. All rights reserved.