Social dominance alters nutrition-related gene expression immediately: transcriptomic evidence from a monomorphic queenless ant.
Social dominance alters nutrition-related gene expression immediately: transcriptomic evidence from a monomorphic queenless ant.
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社会优势立即改变营养相关的基因表达：来自单形无蚁后蚂蚁的转录组证据。
DOI：
10.1111/mec.13989
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发表时间：
2017
影响因子：
4.9
通讯作者：
Mikheyev AS*.
中科院分区：
文献类型：
--
作者：
Okada Y*;Watanabe Y;Mandy MYT;Tsuji K;Mikheyev AS*.
真社会生物中的蚁后-工蜂分化可能起源于母性护理和生殖行为的分离。测序技术的最新进展已经开始阐明蜂王-工蜂分化的分子基础。然而，目前的知识种姓分化的分子基础是有限的，特别是与形态种姓的物种。似乎在形态上未分化的真社会性的黎明，单形女性经历了产生产卵和照顾种姓的生理分化。这种生理分化的分子基础可能提供了进化的洞察力的Eusociality的紧急状态。在这项研究中，我们确定了与单态种姓分化相关的基因，特别是集中在蚁后-工蚁分化的开始，使用单态无后蚂蚁，Diacammasp。从而丧失了形态等级。使用实验操作的个体变得不育或生殖，我们在大脑中确定了1546个种姓偏见的转录本，在胃中确定了10个。由于种姓分化发生inDiacammasoon羽化后，通过行为优势，确定的成绩单被解释为分子代理商立即响应优势等级的形成。在已鉴定的基因中，参与营养加工和储存的基因，如胰岛素信号基因和六聚蛋白的表达水平，在显性等级形成后不久就发生了强烈的变化。我们的结论是，营养相关基因响应社会等级的快速修改可能是迪亚卡马种姓分化的基本机制。结合文献中的功能证据，我们发现一组特定的基因经常在有和没有形态种姓的系统中的生殖分化中发挥作用。
Queen–worker differentiation in eusocial organisms may have originated from decoupling of maternal care and reproductive behaviours. Recent advances in sequencing techniques have begun to elucidate the molecular basis of queen–worker differentiation. However, current knowledge of the molecular basis of caste differentiation is limited, especially to species with morphological castes. It seems likely that at the dawn of eusociality morphologically undifferentiated, monomorphic females underwent physiological differentiation that yielded egg‐laying and caretaking castes. The molecular basis of such physiological differentiation may provide evolutionary insight into the emergent state of eusociality. In this study, we identify genes associated with monomorphic caste differentiation, specifically focusing on the onset of queen–worker differentiation, using a monomorphic queenless ant,Diacammasp., that secondarily lost morphological castes. Using individuals experimentally manipulated to become sterile or reproductive, we identified 1546 caste‐biased transcripts in brain and 10 in gaster. Because caste differentiation occurs inDiacammasoon after eclosion via behavioural dominance, identified transcripts are interpreted as molecular agents responding immediately to dominance rank formation. Among identified genes, expression levels of genes involved in nutrition processing and storage, such as insulin signalling genes andhexamerins, were strongly altered soon after dominance rank formation. We conclude that the rapid modification of nutrition‐related genes in response to social rank may be the fundamental mechanism underlying caste differentiation inDiacamma. Together with functional evidence from the literature, we show that a specific set of genes frequently plays a role in reproductive differentiation across systems with and without morphological castes.