Are proteinases functional molecules of T lymphocytes?
Are proteinases functional molecules of T lymphocytes?
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蛋白酶是T淋巴细胞的功能分子吗？
DOI：
10.1016/0167-5699(87)90141-1
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Simon
中科院分区：
文献类型：
--
作者：
M. Kramer;M. Simon
最近的研究表明，活化的T细胞具有含有一组蛋白酶的胞浆颗粒。本文中，Michael克雷默和Mad（us Simon）认为，这种酶的调节释放在T细胞的活动中起重要作用，如B细胞调节、细胞分裂和迁移。寄生虫和肿瘤通过特定的膜相关受体表达多种效应机制。A~-诱导的T细胞可以杀伤靶细胞并提供调节细胞和体液免疫应答的正或负信号。有充分的证据表明，所有三个T细胞介导的活动-细胞溶解，h~ lp和抑制-与调节分泌的功能分子。许多淋巴因子由活化的T辅助（T ′-h）细胞和/或细胞溶解性T淋巴细胞（CTL）释放，例如白细胞介素2（IL-2）1、干扰素γ（IFN-It）2、B细胞生长和分化因子3、细胞毒素4和溶细胞素/穿孔素5.6。然而，T细胞可以分泌和使用额外的结构-包括酶-来发挥其功能。已经表明T细胞相关蛋白酶在CTL 7.8的细胞杀伤中起重要作用。这一假设得到了以下发现的支持：（i）CTL介导的和自然杀伤（NK）细胞介导的靶细胞裂解被低分子和高分子蛋白酶抑制剂T-1抑制;和（ii）从人外周血白细胞的非细胞群体中分离出细胞溶解性丝氨酸蛋白酶11。最近的一些研究结果表明，蛋白酶也可能参与T细胞介导的体液免疫功能调节12- 1。显示T细胞衍生的胰蛋白酶样蛋白酶参与IgE应答14。B细胞可以被各种外源丝氨酸蛋白酶12.13激活，并且该过程被蛋白酶抑制剂4抑制。最后，蛋白水解酶，特别是丝氨酸蛋白酶，能够降解基底膜样细胞外基质的事实16.17提出了这些酶活性可能促进T细胞迁移到炎症组织中的可能性。在这篇文章中，我们将讨论
Recent studies have shown that activated T cells possess cytoplasmic granules containing a set/he proteinase In this article Michael Kramer and Mad (us Simon suggest that the regulated release of this enzyme has an important part to play in the activities of T cells, such as B-cell regulation, cyto~ is and migrationT lymphocytes are induced by structures such as viruses, bacteria, parasites and tumours via specific membraneassociated receptors to express a variety of effector mechanisms. A~ ivated T cells can kill target cells and provide positive or negative signals that regulate cellular and humoral immune responses. There is good evidence that all three T-cell-mediated activities-cytolysis, h~ lp and suppression-are associated with regulated secretion of functional molecules. A multitude of iymphokines are released by activated T helper (]'-h) cells and/or cytolytic T lymphocytes (CTL) such as interleukin 2 (IL-2) 1, interferon gamma (IFN-It) 2, B-cell growth and differentiation factors 3, lymphotoxin 4 and cytolysin/perforin 5.6. However, T cells may secrete and use additional structures-including enzymes-to exert their functions. It has been suggested that T-cell-associated proteinases play an important role in cell killing by CTL 7.8. This assumption was supported by (i) the finding that CTL-mediated and natural killer (NK) cell-mediated target cell lysis is inhibited by low and high molecular proteinase inhibitorsT-l; and (ii) by isolation of a cytolytic serine proteinase from an unselected population of human peripheral blood leukocytes 11. Several recent findings have indicated that proteinases may also participate in T-cell-mediated regulation of humoral immune functions 12-1s. A T-cell derived trypsin like proteinase was shown to be involved in IgE responses 14. B cells can be polyclonaHy activated by various exogenous serine proteinases 12.13 and this process is suppressed by proteinase inhibitors 4. Finally, the fact that proteolytic enzymes-and serine proteinases in particular-are able to degrade basement membrane-like extracellular matrices 16.17 raises the possibility that these enzymatic activities may facilitate the migration of T cells into inflamed tissue. In this article we would like to discuss
IgE 结合因子生物活性的调节。
DOI：
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发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Iwata,M;Munoz,JJ;Ishizaka,K
通讯作者：
Ishizaka,K
人类淋巴细胞介导的天然细胞毒性 (NK) 对蛋白酶活性的要求：证据表明蛋白酶是丝氨酸依赖性的，并且具有芳香族氨基酸裂解特异性。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hudig,D;Redelman,D;Minning,LL
通讯作者：
Minning,LL