Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration
Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration
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DOI：
10.1159/000102935
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Neumaier, Michael
中科院分区：
文献类型：
--
作者：
Jonas, Jost B.;Neumaier, Michael
背景资料：目的探讨视网膜新生血管性或水肿性病变中血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）的含量。研究方法：采用固相化学发光免疫分析法检测35例渗出型老年性黄斑变性（AMD）患者、21例糖尿病性黄斑水肿患者和24例对照组患者房水中VEGF和bFGF的浓度。结果如下：糖尿病组VEGF和bFGF的浓度明显高于对照组（184.7 +/- 107.0和5.0 +/- 10.2 pg/l）（107.7 +/- 73.0 pg/l，p = 0.002; 2.2 +/- 7.4 pg/ l，p = 0.002）和对照组（71.5 +/- 94.7 pg/ l，p = 0.001; 0.00 pg/ l，p = 0.001）。后两组无显著差异（p = 0.10）。结论：VEGF和bFGF在患有糖尿病性黄斑水肿的眼睛中的浓度显著高于患有渗出性AMD的眼睛或正常眼睛。VEGF的差异比bFGF更显著。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: To evaluate the concentrations of vascular endothelial growth factor ( VEGF) and basic fibroblast growth factor ( bFGF) in neovascular or edematous retinal diseases. Methods: In the clinical comparative interventional study, VEGF and bFGF concentrations in aqueous humor samples of 35 patients with exudative age- related macular degeneration ( AMD), 21 patients with diabetic macular edema and 24 patients of a control group were measured using a solid-phase chemiluminescence immunoassay. Results: Concentrations of VEGF and bFGF, respectively, were significantly higher in the diabetic group ( 184.7 +/- 107.0 and 5.0 +/- 10.2 pg/l) than in the AMD group ( 107.7 +/- 73.0 pg/l, p = 0.002; 2.2 +/- 7.4 pg/ l, p = 0.002) and the control group ( 71.5 +/- 94.7 pg/ l, p = 0.001; 0.00 pg/ l, p = 0.001). The two latter groups did not vary significantly ( p = 0.10). Conclusions: VEGF and bFGF are present in considerably higher concentrations in eyes with diabetic macular edema than in eyes with exudative AMD or normal eyes. The differences were more marked for VEGF than for bFGF. Copyright (c) 2007 S. Karger AG, Basel.