Reduced ratio of active-to-total urinary kallikrein in essential hypertension.
Reduced ratio of active-to-total urinary kallikrein in essential hypertension.
复制标题
原发性高血压患者尿中活性激肽释放酶与总尿激肽释放酶的比率降低。
DOI：
10.1161/01.hyp.5.4.603
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Levinsky,NG
中科院分区：
文献类型：
--
作者：
Lieberthal,W;Arbeit,L;Oza,NB;Bernard,DB;Levinsky,NG
尿激肽释放酶排泄进行了研究，在34例轻度，正常的肾素，原发性高血压没有证据的靶器官损害和23名血压正常的控制，使用测定活性（激肽原酶活性）和总（活性加非活性）激肽释放酶。两组之间的活性或总激肽释放酶排泄量无显著差异。然而，与血压正常者（1.00 +/- 0.05单位/微克）相比，高血压者（0.83 +/- 0.03单位/微克）的活性酶与总酶的比率降低（p <0.002）。两组中活性酶与总酶的比值与钠排泄呈负相关，表明活性酶与非活性酶的比例随着钠摄入量的减少而增加。我们的结论是，虽然绝对排泄的活性和总激肽释放酶没有减少，酶活性每微克总激肽释放酶排泄减少轻度，正常的原发性高血压。这种异常可能是由于有缺陷的酶，或减少排泄的活性相对于非活性激肽释放酶。后者可能是由于尿激肽释放酶抑制剂的存在或酶原的活化减少。
Urinary kallikrein excretion was studied in 34 patients with mild, normal-renin, essential hypertension without evidence of target organ damage and in 23 normotensive controls, using assays that measure both active (kininogenase activity) and total (active plus inactive) kallikrein. There was no significant difference in either active or total kallikrein excretion between the two groups. However, the ratio of active-to-total enzyme was decreased in the hypertensives (0.83 +/- 0.03 units/micrograms) compared to the normotensives (1.00 +/- 0.05 units/micrograms) (p less than 0.002). The active-to-total ratio was inversely related to sodium excretion in both groups, indicating that the proportion of active to inactive enzyme increased in response to reduced sodium intake. We conclude that, although absolute excretion of active and total kallikrein is not decreased, enzyme activity per microgram of total kallikrein excreted is reduced in mild, normal-renin essential hypertension. This abnormality may be due to a defective enzyme, or to a reduced excretion of active relative to inactive kallikrein. The latter could result from the presence of a urinary kallikrein inhibitor or to reduced activation of a proenzyme.