Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study.
Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study.
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发表时间：
1994-05
影响因子：
6.5
通讯作者：
E. Schaefer;S. Lamon-Fava;Susan D. Cohn;M. M. Schaefer-M.;J. Ordovás;W. Castelli;P. Wilson
中科院分区：
文献类型：
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作者：
E. Schaefer;S. Lamon-Fava;Susan D. Cohn;M. M. Schaefer-M.;J. Ordovás;W. Castelli;P. Wilson
在参加第三个检查周期的 1,533 名男性（平均年龄 49 +/- 10 岁）和 1,597 名女性（平均年龄 49 +/- 10 岁）中测量了血浆低密度脂蛋白 (LDL) 胆固醇、非高密度脂蛋白 (HDL) 胆固醇和载脂蛋白 (apo) B（LDL 的主要蛋白质成分）。 弗雷明汉后代研究。男性 LDL 胆固醇和 apoB 的平均血浆水平高于女性（136 与 132 mg/dl，P 或 = 125 mg/dl 可能与 CHD 风险增加相关。低血浆 HDL 胆固醇水平也与 CHD 显着相关。血浆甘油三酯水平、年龄和体重指数是 LDL 胆固醇、非 HDL 胆固醇、 以及男性和女性的 apoB 水平。在女性中，绝经后状态和血压升高也与这些参数水平升高显着相关。
Plasma low density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, and apolipoprotein (apo) B, the major protein constituent of LDL, were measured in 1,533 men (mean age 49 +/- 10 years) and 1,597 women (mean age 49 +/- 10 years) participating in the 3rd examination cycle of the Framingham Offspring Study. Mean plasma levels of LDL cholesterol and apoB were higher in men than in women (136 versus 132 mg/dl, P or = 125 mg/dl may be associated with an increased risk for CHD. Low plasma levels of HDL cholesterol were also significantly associated with CHD. Plasma triglyceride levels, age and body mass index were strong determinants of LDL cholesterol, non-HDL cholesterol, and apoB levels in men and women. In women, postmenopausal status and elevated blood pressure were also significantly associated with elevated levels of these parameters.