Effects of hemodynamic alterations on wall motion in the canine right ventricle.
Effects of hemodynamic alterations on wall motion in the canine right ventricle.
复制标题
血流动力学改变对犬右心室室壁运动的影响。
DOI：
10.1152/ajpheart.1979.236.2.h254
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
A. Bove
中科院分区：
文献类型：
--
作者：
W. Santamore;G. D. Meier;A. Bove
通过测量长期植入的右心室游离壁上透射线标记物与室间隔之间的距离，分析了6只闭胸、麻醉、定步犬右心室壁上的局部运动。正常情况下，窦区比圆锥区早25毫秒开始收缩。最大的缩短速度发生在圆锥区（2.42 +/- 0.33长度/s）和隔膜-自由壁方向（2.56 +/- 0.40 l/s）。所有地区的缩短率在12%到17%之间。数据表明右心室通过自由壁表面积和间隔与自由壁距离的均匀减小来喷射血液。静脉回流减少，舒张末期长度、缩短百分比、最大缩短速度和到达收缩末期长度的时间缩短。右心室压力过载增加舒张末期长度，降低缩短百分比和最大缩短速度。低压过载导致非均匀收缩模式。缩短百分比和最大缩短速度在纵向和纵向上减小，在纵向和纵向上增大；这些变化表明左室和左室之间的机械相互作用。
Regional right ventricular (RV) wall motion was analyzed in six closed-chest, anesthetized, paced dogs by measuring distances between chronically implanted radiopaque markers on RV free wall and septum. Normally, contraction started in the sinus region 25 ms before conus region. Highest velocities of shortening occurred in the conus region (2.42 +/- 0.33 lengths/s) and in septum-to-free-wall direction (2.56 +/- 0.40 l/s). Percent shortening for all regions was between 12% and 17%. The data indicate that the RV ejects blood by a uniform reduction in its free wall surface area and septal-to-free-wall distance. Reduced venous return decreased end-diastolic length, percent shortening, maximum velocity of shortening, and time to end-systolic length. RV pressure overload increased end-diastolic length and decreased percent shortening and maximum velocity of shortening. LV pressure overload led to a nonhomogeneous contraction pattern. Percent shortening and maximum velocity of shortening increased in sinal and conal transverse directions and decreased in sinal and conal longitudinal directions; these changes indicate a mechanical interaction between RV and LV.