PAN-orama: three convergent views of a eukaryotic deadenylase.
PAN-orama: three convergent views of a eukaryotic deadenylase.
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PAN-orama：真核去腺苷酶的三种趋同观点。
DOI：
10.1038/nsmb.2850
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发表时间：
2014
影响因子：
16.8
通讯作者：
Coller,Jeff
中科院分区：
文献类型：
--
作者：
Martin,Sophie;Coller,Jeff
转录后的mRNA调控通常是通过延长或缩短转录本的3‘聚(A)尾来实现的。真核细胞的mRNAs显示出一系列去烯化速率，因此可以对基因表达进行复杂的控制，但决定这种速率的机制尚不清楚。三项新的研究强调了去除聚(A)尾的关键酶-PAN2-PAN3复合体的结构和生化特征，为如何实现不同的mRNA去烯化速率提供了线索。
Post-transcriptional mRNA regulation is often attained by lengthening or shortening the 3′ poly(A) tail of a transcript. Eukaryotic mRNAs show a spectrum of deadenylation rates, thus allowing intricate control of gene expression, but the mechanisms that determine such rates are unclear. Three new studies highlight the structural and biochemical features of a key enzyme in removing poly(A) tails, the PAN2–PAN3 complex, providing clues to how different mRNA deadenylation rates can be achieved.